3-(3,4-二甲氧基苯基)-3-氧丁酸乙酯合成路线 （共 8 条）
反应条件
1: 2,2-Dimethyl-[1,3]dioxane-4,6-dione; 3,4-Dimethoxy-phenylacetic acid chloride With pyridine in dichloromethane
T=0 - 23°C; 8 h;
2: With hydrogenchloride in water
3: ethanol T=75°C; 11 h;
参考文献
Krishnan, Shyam; Bagdanoff, Jeffrey T.; Ebner, David C.; Ramtohul, Yeeman K.; Tambar, Uttam K.; Stoltz, Brian M.
Journal of the American Chemical Society, 2008 , vol. 130, # 41 p. 13745 - 13754
反应条件
1: thionyl chloride; DMF / benzene / 3 h
2: pyridine / CH2Cl2 / 8 h / 20 °C
3: 1.31 g / 11 h / 75 °C
View Scheme
参考文献
Tambar, Uttam K.; Ebner, David C.; Stoltz, Brian M.
Journal of the American Chemical Society, 2006 , vol. 128, # 36 p. 11752 - 11753
反应条件
1: pyridine / CH2Cl2 / 8 h / 20 °C
2: 1.31 g / 11 h / 75 °C
View Scheme
参考文献
Tambar, Uttam K.; Ebner, David C.; Stoltz, Brian M.
Journal of the American Chemical Society, 2006 , vol. 128, # 36 p. 11752 - 11753
反应条件
1: With methanesulfonic acid; zinc in tetrahydrofuran
Blaise reaction; 0.5 h;
2: With hydrogenchloride in tetrahydrofuran
参考文献
Shin, Hyunik; Choi, Bo Seung; Lee, Ki Kon; Choi, Hyeong-Wook; Chang, Jay Hyok; Lee, Kyu Woong; Nam, Do Hyun; Kim, No-Soo
Synthesis, 2004 , # 16 p. 2629 - 2632
反应条件
3 h; Heating; Yield given;
参考文献
Capozzi; Roelens; Talami
Journal of Organic Chemistry, 1993 , vol. 58, # 27 p. 7932 - 7936
反应条件
T=-65°C; 0.0833333 h;
参考文献
Schinzer, Dieter; Abel, Ulrich; Jones, Peter G.
Synlett, 1997 , # 5 p. 632 - 634
参考文献
Takano
Yakugaku Zasshi, 1959 , vol. 79, p. 1449
Chem.Abstr., 1960 , p. 6630
反应条件
1: sodium ethylate
2: aq.-ethanolic HCl
View Scheme
参考文献
Takano
Yakugaku Zasshi, 1959 , vol. 79, p. 1449
Chem.Abstr., 1960 , p. 6630
