2-氧代-4-苯吡咯烷-3-羧酸合成路线 （共 7 条）
参考文献
Journal of the American Chemical Society, , vol. 66, p. 1883
反应条件
potassium hydroxide 5 h; Heating;
参考文献
Glozman, O. M.; Morozov, I. S.; Zhmurenko, L. A.; Zagorevskii, V. A.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 11 p. 776 - 780
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 11 p. 43 - 48
反应条件
1: 58 percent / 0.5 h / 190 °C 2: 1.) NaH / 1.) dioxane, 90 deg C, 1 h, 2.) 125 deg C, 5 h 3: 100 percent / NH3 / methanol / 5 h / 45 - 50 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 14, # 11 p. 776 - 780
Khimiko-Farmatsevticheskii Zhurnal, , vol. 14, # 11 p. 43 - 48
反应条件
1: 58 percent / 0.5 h / 190 °C 2: 1.) NaH / 1.) dioxane, 90 deg C, 1 h, 2.) 125 deg C, 5 h 3: 80 percent / KOH / aq. ethanol / 3 h / Heating View Scheme
参考文献
Glozman, O. M.; Morozov, I. S.; Zhmurenko, L. A.; Zagorevskii, V. A.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 11 p. 776 - 780
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 11 p. 43 - 48
反应条件
sulfuric acid in ethanol T=120°C; 0.166667 h;
参考文献
ACADIA PHARMACEUTICALS INC.
Patent: WO2006/127396 A1, 2006 ;
Location in patent: Page/Page column 33 ;
WO 2006/127396 A1
参考文献
Glozman, O. M.; Morozov, I. S.; Zhmurenko, L. A.; Zagorevskii, V. A.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 11 p. 776 - 780
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 11 p. 43 - 48
反应条件
1: 58 percent / 0.5 h / 190 °C
2: 1.) NaH / 1.) dioxane, 90 deg C, 1 h, 2.) 125 deg C, 5 h
View Scheme
参考文献
Glozman, O. M.; Morozov, I. S.; Zhmurenko, L. A.; Zagorevskii, V. A.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 11 p. 776 - 780
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 11 p. 43 - 48
