1: (EtO)2P(O)CH2NC With potassium tert-butylate in dichloromethane
T=-78°C; 0.25 h;
2: benzyl bromide in dichloromethane
T=20°C;
3: With hydrogenchloride; ethanol; water; potassium carbonate
more than 3 stages;
参考文献
SEATTLE GENETICS, INC.
Patent: WO2007/8848 A2, 2007 ;
Location in patent: Page/Page column 140; 141 ;