3-[5-(2-氟苯基)-1,2,4-恶二唑-3-基]苯甲酸合成路线 （共 3 条）
反应条件
1: With sodium hydroxide; water T=100°C; 2 h; Heating / reflux; 2: With hydrogenchloride in water
参考文献
PTC THERAPEUTICS, INC.
Patent: WO2007/117438 A2, 2007 ;
Location in patent: Page/Page column 261 ;
反应条件
1: 3-cyano-benzoic acid With hydroxylamine in water; tert-butyl alcohol T=38 - 41°C; 21 h; 2: 2-fluoro-benzoyl chloride With triethylamine in water; tert-butyl alcohol T=27 - 40°C; 7 h; 3: With hydrogenchloride; water Product distribution / selectivity; more than 3 stages;
参考文献
PTC THERAPEUTICS, INC.
Patent: WO2008/30570 A1, 2008 ;
Location in patent: Page/Page column 23-24 ;
反应条件
1: boron trifluoride diethyl etherate / 1,4-dioxane / 12.5 h / 0 °C / |Reflux 2: sodium hydroxide; water / ethanol / 3 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 11 p. 2473 - 2476
