4-((三甲基甲硅烷基)乙炔)苯磺酰胺合成路线 （共 3 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C;
参考文献
PHARMACIA CORPORATION
Patent: WO2004/87686 A2, 2004 ;
Location in patent: Page 229 ;
Title/Abstract Full Text Show Details
PHARMACIA CORPORATION
Patent: WO2004/87687 A1, 2004 ;
Location in patent: Page 229 ;
WO 2004/087687 A1
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride
T=90°C; Sonogashira cross-coupling;
参考文献
Chowdhury, Morshed Alam; Dong, Ying; Chen, Qiao-Hong; Abdellatif, Khaled R.A.; Knaus, Edward E.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 4 p. 1948 - 1956
反应条件
copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine
Sonogashira coupling;
参考文献
Wilkinson, Brendan L.; Innocenti, Alessio; Vullo, Daniela; Supuran, Claudiu T.; Poulsen, Sally-Ann
Journal of Medicinal Chemistry, 2008 , vol. 51, # 6 p. 1945 - 1953
