2-(甲基氨基)-苯甲醛合成路线 （共 16 条）
反应条件
1: diethyl ether / 20 °C 2: sodium hydride / tetrahydrofuran / Heating; or r.t. View Scheme
参考文献
Kolodyazhnyi, O. I.; Grishkun, E. V.; Yakovlev, V. I.; Kukhar', V. P.
J. Gen. Chem. USSR (Engl. Transl.), 1990 , vol. 60, # 5 p. 1050 - 1053,926 - 929
反应条件
1: methyllithium With zinc(II) chloride in tetrahydrofuran
T=-78 - 20°C;
2: 2,1-benzisoxazole With bis(acetylacetonate)nickel(II) in tetrahydrofuran
参考文献
Heaney, Frances; McCarthy, Tomas; Mahon, Mary; McKee
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 24 p. 4351 - 4361
反应条件
potassium hydroxide; dihydrogen peroxide in water; 1,2-dichloro-ethane
T=20°C; 48 h;
参考文献
Lee, Yong Rok; Hung, Thai Viet
Tetrahedron, 2008 , vol. 64, # 30-31 p. 7338 - 7346
反应条件
1: 1.) 3-chloroperoxybenzoic acid, 2.) NaOH / 1.) CHCl3, room temperature, 20 min, 2.) reflux, 1.5 h
2: 73 percent / H2 / Pd-C / ethyl acetate / 2 h / 760 Torr / Ambient temperature
3: 68 percent / n-BuLi / tetrahydrofuran / -105 deg C -> room temperature, 1.5 h
4: W-2 Raney nickel / ethanol / 1 h / Ambient temperature
View Scheme
参考文献
Sisko, Joseph; Weinreb, Steven M.
Synthetic Communications, 1988 , vol. 18, # 10 p. 1035 - 1042
反应条件
1: 68 percent / n-BuLi / tetrahydrofuran / -105 deg C -> room temperature, 1.5 h
2: W-2 Raney nickel / ethanol / 1 h / Ambient temperature
View Scheme
参考文献
Sisko, Joseph; Weinreb, Steven M.
Synthetic Communications, 1988 , vol. 18, # 10 p. 1035 - 1042
反应条件
1: 73 percent / H2 / Pd-C / ethyl acetate / 2 h / 760 Torr / Ambient temperature
2: 68 percent / n-BuLi / tetrahydrofuran / -105 deg C -> room temperature, 1.5 h
3: W-2 Raney nickel / ethanol / 1 h / Ambient temperature
View Scheme
参考文献
Sisko, Joseph; Weinreb, Steven M.
Synthetic Communications, 1988 , vol. 18, # 10 p. 1035 - 1042
反应条件
W-2 Raney nickel in ethanol
1 h; Ambient temperature;
参考文献
Sisko, Joseph; Weinreb, Steven M.
Synthetic Communications, 1988 , vol. 18, # 10 p. 1035 - 1042
反应条件
triethylamine
0.5 h;
参考文献
McKinnon, David M.; Duncan, K. Ann; Millar, Lesley M.
Canadian Journal of Chemistry, 1982 , vol. 60, p. 440 - 444
反应条件
1.1: 1,4-dioxane / 1 h / |Reflux
2.1: potassium hydroxide / water; dichloromethane
2.2: 48 h
View Scheme
参考文献
Ghandi, Mehdi; Sheibani, Shahab; Sadeghzadeh, Masoud; Daha, Fariba Johari; Kubicki, MacIej
Journal of the Iranian Chemical Society, 2013 , vol. 10, # 6 p. 1057 - 1065
参考文献
McKinnon, David M.; Duncan, K. Ann; Millar, Lesley M.
Canadian Journal of Chemistry, 1982 , vol. 60, p. 440 - 444
