1-(吡啶-2-基)-1 H-吡唑-4-甲酸合成路线 （共 6 条）
反应条件
1: triethylamine; diphenyl phosphoryl azide / 3 h / 90 °C 2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; BLEICHER, Konrad; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; KUHN, Bernd; PETERS, Jens-Uwe; RODRIGUEZ SARMIENTO, Rosa Maria; VIEIRA, Eric
Patent: WO2011/89132 A1, 2011 ;
WO 2011/089132 A1
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran; ethanol
T=0 - 20°C; 7 h;
参考文献
F. HOFFMANN-LA ROCHE AG; BLEICHER, Konrad; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; KUHN, Bernd; PETERS, Jens-Uwe; RODRIGUEZ SARMIENTO, Rosa Maria; VIEIRA, Eric
Patent: WO2011/89132 A1, 2011 ;
Location in patent: Page/Page column 96 ;
WO 2011/089132 A1
反应条件
1: 65 percent / Cs2CO3 / dimethylformamide / 140 °C
2: 90 percent / KOH / ethanol; H2O
View Scheme
参考文献
Warshakoon, Namal C.; Wu, Shengde; Boyer, Angelique; Kawamoto, Richard; Renock, Sean; Xu, Kevin; Pokross, Matthew; Evdokimov, Artem G.; Zhou, Songtao; Winter, Carol; Walter, Richard; Mekel, Marlene
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5687 - 5690
反应条件
1: 69 percent / conc. H2SO4, conc. HNO3 / 1.) 0 deg C - 5 deg C; 2.) 2 h, room temperature
2: 46 percent / cuprous cyanide / dimethylsulfoxide / 5 h / 150 °C
3: 10percent aq. NaOH / Heating
View Scheme
参考文献
Khan, Misbahul Ain; Pinto, Alvaro Augusto Alves
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 9 - 14
反应条件
1: 46 percent / cuprous cyanide / dimethylsulfoxide / 5 h / 150 °C
2: 10percent aq. NaOH / Heating
View Scheme
参考文献
Khan, Misbahul Ain; Pinto, Alvaro Augusto Alves
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 9 - 14
反应条件
sodium hydroxide
Heating;
参考文献
Khan, Misbahul Ain; Pinto, Alvaro Augusto Alves
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 9 - 14
