1,3-二氢-1-丙基-(9ci)-2H-苯并咪唑-2-酮合成路线 （共 8 条）
反应条件
hydrogenchloride in water
T=60°C; 1 h;
参考文献
Vernin, Gaston; Domlog, Hicham; Siv, Chan; Metzger, Jaques; El-Shafei, Ahmed Kamal
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 85 - 89
反应条件
potassium hydroxide; [bis(acetoxy)iodo]benzene in methanol
T=0°C; 1 h;
参考文献
Prakash; Batra; Kaur; Sharma; Singh; Moriarty
Synthesis, 2001 , # 4 p. 541 - 543
反应条件
sodium azide in acetic acid
5 h; Heating;
参考文献
Essawy, A.; El-Hashash, M. A.; El-Gendy, A. M.; Hamad, M. M. M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 6 p. 593 - 595
反应条件
1: 95 percent / 50percent aq. NaOH / triethylbutylammonium chloride / benzene / 1 h / 60 °C
2: 95 percent / conc. hydrochloric acid / H2O / 1 h / 60 °C
View Scheme
参考文献
Vernin, Gaston; Domlog, Hicham; Siv, Chan; Metzger, Jaques; El-Shafei, Ahmed Kamal
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 85 - 89
反应条件
1: 75 percent / 0.08 h / 150 °C
2: 95 percent / 50percent aq. NaOH / triethylbutylammonium chloride / benzene / 1 h / 60 °C
3: 95 percent / conc. hydrochloric acid / H2O / 1 h / 60 °C
View Scheme
参考文献
Vernin, Gaston; Domlog, Hicham; Siv, Chan; Metzger, Jaques; El-Shafei, Ahmed Kamal
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 85 - 89
反应条件
in tetrahydrofuran
T=20°C;
参考文献
Zhang, Puwen; Terefenko, Eugene A.; McComas, Casey C.; Mahaney, Paige E.; Vu, An; Trybulski, Eugene; Koury, Elizabeth; Johnston, Grace; Bray, Jenifer; Deecher, Darlene
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6067 - 6070
反应条件
sodium hydride
1.) DMF, 1 h, 2.) DMF, RT, 24 h; Yield givenMultistep reaction;
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
反应条件
Yield given. Multistep reaction;
参考文献
Meanwell; Sit; Gao; Wong; St. Laurent; Balasubramanian
Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1565 - 1582
