1-丁基-1H-苯并咪唑-2-醇合成路线 （共 7 条）
反应条件
iodosylbenzene in dichloromethane
T=20°C; Hofmann rearrangement; 2 h;
参考文献
Liu, Peng; Wang, Zhiming; Hu, Xianming
European Journal of Organic Chemistry, 2012 , # 10 p. 1994 - 2000
反应条件
hydrogenchloride in water
T=60°C; 1 h;
参考文献
Vernin, Gaston; Domlog, Hicham; Siv, Chan; Metzger, Jaques; El-Shafei, Ahmed Kamal
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 85 - 89
反应条件
copper(l) iodide; N,N,N',N,-tetramethylethylenediamine in water
T=120°C; 15 h;
参考文献
Barbero, Nekane; Carril, Monica; SanMartin, Raul; Dominguez, Esther
Tetrahedron, 2008 , vol. 64, # 30-31 p. 7283 - 7288
反应条件
1: 90 percent / 50percent aq. NaOH / triethylbutylammonium chloride / benzene / 1 h / 60 °C
2: 95 percent / conc. hydrochloric acid / H2O / 1 h / 60 °C
View Scheme
参考文献
Vernin, Gaston; Domlog, Hicham; Siv, Chan; Metzger, Jaques; El-Shafei, Ahmed Kamal
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 85 - 89
反应条件
1: 75 percent / 0.08 h / 150 °C
2: 90 percent / 50percent aq. NaOH / triethylbutylammonium chloride / benzene / 1 h / 60 °C
3: 95 percent / conc. hydrochloric acid / H2O / 1 h / 60 °C
View Scheme
参考文献
Vernin, Gaston; Domlog, Hicham; Siv, Chan; Metzger, Jaques; El-Shafei, Ahmed Kamal
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 85 - 89
反应条件
sodium hydride
1.) DMF, 2.) DMF, RT; Multistep reaction;
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
参考文献
Bednjagina; Postowskii
Chimija chim. Technol. (NDVS)Chem.Abstr., 1959 <333, 334 1960 , p. 509
