巨大戟醇-5,20-缩丙酮合成路线 （共 8 条）
反应条件
hydrogenchloride; water in methanol T=20°C; 1 h;
参考文献
Synlett, , vol. 23, # 18 p. 2647 - 2652
反应条件
1: sodium hydrogencarbonate / toluene / 22 h / 100 °C 2: hydrogenchloride; water; methanol / 1 h / 20 °C View Scheme
反应条件
1: sodium hydrogencarbonate / toluene / 22 h / 100 °C 2: water; methanesulfonic acid / tetrahydrofuran / 72 h / 20 °C View Scheme
反应条件
perchloric acid in methanol 1 h;
参考文献
Opferkuch, H. J.; Adolf, W.; Sorg, B.; Kusumoto, S.; Hecker, E.
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1981 , vol. 36, # 7 p. 878 - 887
反应条件
1: 66 percent / 70percent perchloric acid / methanol / 1 h 2: 103 mg / phosphorpentoxid 3: 31 percent / 70percent perchloric acid / methanol / 0.75 h View Scheme
参考文献
Opferkuch, H. J.; Adolf, W.; Sorg, B.; Kusumoto, S.; Hecker, E.
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1981 , vol. 36, # 7 p. 878 - 887
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C;
参考文献
LEO PHARMA A/S; HOeGBERG, Thomas; GRUE-SOERENSEN, Gunnar; LIANG, Xifu; HORNEMAN, Anne, Marie; PETERSEN, Anders,, Klarskov
Patent: WO2012/10172 A1, 2012 ;
Location in patent: Page/Page column 51-52 ;
反应条件
tributyl-amine; 2-chloro-1-methyl-pyridinium iodide in toluene T=60°C; 18 h;
参考文献
LEO PHARMA A/S; HOeGBERG, Thomas; GRUE-SOERENSEN, Gunnar; LIANG, Xifu; HORNEMAN, Anne, Marie; PETERSEN, Anders,, Klarskov
Patent: WO2012/10172 A1, 2012 ;
Location in patent: Page/Page column 51-52 ;
反应条件
1: 4-(N,N-dimethylamino)pyridine / toluene / 2 h
2: 82 percent / 70 percent HClO4 / methanol / 0.75 h
View Scheme
参考文献
Roeser, H.; Sorg, B.; Hecker, E.
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 7 p. 1026 - 1030
