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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
77581-28-3
合成路线
（共 22 条）
77581-28-3
→
反应条件
352535-68-3
(2S)-(?)-2-(羟基二苯甲基)-1--甲酸甲酯
反应条件
1: tetrahydrofuran / Heating 2: 90 percent / KOH / methanol / 4 h / Heating 3: 90 percent / Et3N / diethyl ether / 20 °C View Scheme
参考文献
Sibi, Mukund P.; Manyem, Shankar
Organic Letters, 2002 , vol. 4, # 17 p. 2929 - 2932
77581-28-3
→
反应条件
848821-58-9
(2S)-2-[二苯基[(三甲基硅酯)氧基]甲基]-吡咯烷
反应条件
1.1: tetrahydrofuran / 20 °C / Inert atmosphere 1.2: 16 h / Reflux; Inert atmosphere 2.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Khong, San N.; Kwon, Ohyun
Molecules, 2012 , vol. 17, # 5 p. 5626 - 5650
27607-77-8
三氟甲磺酸三甲基硅酯
+
69739-34-0
叔丁基二甲硅基三氟甲磺酸酯
+
77581-28-3
+
100-58-3
溴化苯基镁
+
13139-86-1
3-甲基-CBS-氧硼啶
→
反应条件
848821-58-9
(2S)-2-[二苯基[(三甲基硅酯)氧基]甲基]-吡咯烷
反应条件
1: (S)-1-ethyl 2-methyl pyrrolidine-1,2-dicarboxylate; phenyl-magnesium bromide; 4-methoxyphenyl magnesium bromide in tetrahydrofuran T=0°C; Grignard reaction; 3.5 h; Inert atmosphere; 2: With potassium hydroxide in methanol 24 h; Reflux; 3: trimethylsilyl trifluoromethanesulfonate; t-butyldimethylsiyl triflate With 2,6-dimethylpyridine in dichloromethane T=0 - 20°C; 12 h;
参考文献
Fleischer, Ivana; Pfaltz, Andreas
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 95 - 99
77581-28-3
+
100-58-3
溴化苯基镁
→
反应条件
22348-32-9
(R)-(+)-α,α-二苯基脯氨醇
反应条件
1: in tetrahydrofuran T=20°C; Inert atmosphere; 2: With potassium hydroxide in methanol 16 h; RefluxInert atmosphere;
参考文献
Khong, San N.; Kwon, Ohyun
Molecules, 2012 , vol. 17, # 5 p. 5626 - 5650
77581-28-3
→
反应条件
22348-32-9
(R)-(+)-α,α-二苯基脯氨醇
反应条件
1.1: Mg; iodine / tetrahydrofuran / Heating 1.2: 45 percent / tetrahydrofuran / Heating 2.1: 15 percent / KOH / methanol / 4 h / Heating View Scheme
参考文献
Li, Kangying; Zhou, Zhenghong; Wang, Lixin; Chen, Qifa; Zhao, Guofeng; Zhou, Qilin; Tang, Chuchi
Tetrahedron Asymmetry, 2003 , vol. 14, # 1 p. 95 - 100
77581-28-3
+
100-58-3
溴化苯基镁
+
13139-86-1
3-甲基-CBS-氧硼啶
→
反应条件
22348-32-9
(R)-(+)-α,α-二苯基脯氨醇
+
1208864-95-2
+
131180-57-9
反应条件
1: in tetrahydrofuran T=0°C; Grignard reaction; 3.5 h; Inert atmosphere; 2: With potassium hydroxide in methanol 24 h; Reflux;
参考文献
Fleischer, Ivana; Pfaltz, Andreas
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 95 - 99
77581-28-3
→
反应条件
22348-31-8
反应条件
1: 82 percent / tetrahydrofuran / 3 h / Heating 2: 86 percent / H2 / Pd/C / methanol / 48 h / Ambient temperature View Scheme
参考文献
Bailey, David J.; O'Hagan, David; Tavasli, Mustafa
Tetrahedron Asymmetry, 1997 , vol. 8, # 1 p. 149 - 153
77581-28-3
→
反应条件
274674-23-6
(S)-2-(氟二苯甲基)吡咯烷
反应条件
1: 70 percent / tetrahydrofuran / 0 - 65 °C 2: 82 percent / HF*pyridine / 24 h / 0 - 20 °C View Scheme
参考文献
Ho, Chun-Yu; Chen, Ying-Chun; Wong, Man-Kin; Yang, Dan
Journal of Organic Chemistry, 2005 , vol. 70, # 3 p. 898 - 906
77581-28-3
→
反应条件
131180-45-5
反应条件
1: tetrahydrofuran / 20 °C 2: KOH / methanol / 4 h View Scheme
参考文献
Li, Kangying; Zhou, Zhenghong; Wang, Lixin; Chen, Qifa; Zhao, Guofeng; Zhou, Qilin; Tang, Chuchi
Tetrahedron Asymmetry, 2003 , vol. 14, # 1 p. 95 - 100
77581-28-3
+
100-58-3
溴化苯基镁
+
13139-86-1
3-甲基-CBS-氧硼啶
→
反应条件
22348-32-9
(R)-(+)-α,α-二苯基脯氨醇
+
1208864-95-2
+
131180-57-9
反应条件
1: in tetrahydrofuran T=0°C; Grignard reaction; 3.5 h; Inert atmosphere; 2: With potassium hydroxide in methanol 24 h; Reflux;
参考文献
Chemistry - A European Journal, , vol. 16, # 1 p. 95 - 99
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