2,3,5,6-四氟对二溴苄合成路线 （共 14 条）
反应条件
1.1: n-BuLi / tetrahydrofuran / -25 °C
1.2: 76 percent / tetrahydrofuran / -25 - 20 °C
2.1: 72 percent / TFA; aq. HCl / 0.33 h / 55 °C
3.1: 83 percent / (CH3)2S*BH3 / tetrahydrofuran / 0.25 h / 0 °C
4.1: 63 percent / PBr3 / 1 h / Heating
View Scheme
参考文献
Krebs, Frederik C.; Jensen, Thomas
Journal of Fluorine Chemistry, 2003 , vol. 120, # 1 p. 77 - 84
反应条件
1: 72 percent / TFA; aq. HCl / 0.33 h / 55 °C
2: 83 percent / (CH3)2S*BH3 / tetrahydrofuran / 0.25 h / 0 °C
3: 63 percent / PBr3 / 1 h / Heating
View Scheme
参考文献
Krebs, Frederik C.; Jensen, Thomas
Journal of Fluorine Chemistry, 2003 , vol. 120, # 1 p. 77 - 84
反应条件
1.1: n-BuLi / tetrahydrofuran / 0.25 h / -60 °C
1.2: 73 percent / tetrahydrofuran / -60 - 20 °C
2.1: 43 percent / aq. TFA / 2 h / Heating
3.1: 83 percent / (CH3)2S*BH3 / tetrahydrofuran / 0.25 h / 0 °C
4.1: 63 percent / PBr3 / 1 h / Heating
View Scheme
参考文献
Krebs, Frederik C.; Jensen, Thomas
Journal of Fluorine Chemistry, 2003 , vol. 120, # 1 p. 77 - 84
反应条件
1: 43 percent / aq. TFA / 2 h / Heating
2: 83 percent / (CH3)2S*BH3 / tetrahydrofuran / 0.25 h / 0 °C
3: 63 percent / PBr3 / 1 h / Heating
View Scheme
参考文献
Krebs, Frederik C.; Jensen, Thomas
Journal of Fluorine Chemistry, 2003 , vol. 120, # 1 p. 77 - 84
