3-(2-羧基苯基)丙酸合成路线 （共 67 条）
反应条件
1: sulfuric acid / 2 h / 20 °C
2: lithium borohydride / 1,4-dioxane / 6.5 h / 100 °C / |Inert atmosphere
3: sulfuric acid / 36 h / |Reflux
4: pyridinium chlorochromate; silica gel / dichloromethane / 20 °C
View Scheme
参考文献
Zhao, Jin; Dong, Hong-Bo; Yang, Ming-Yan; Du, Juan; Jiang, Jia-Zheng; Wang, Ming-An
Journal of Asian Natural Products Research, 2014 , vol. 16, # 3 p. 312 - 317
反应条件
1: LiAlH4; diethyl ether
2: N,N-dimethyl-aniline; chloroform; thionyl chloride
3: aq.-ethanolic KOH
4: H2SO4
View Scheme
参考文献
Page; Tarbell
Journal of the American Chemical Society, 1953 , vol. 75, p. 2053
反应条件
1: LiAlH4; diethyl ether
2: N,N-dimethyl-aniline; chloroform; thionyl chloride
View Scheme
参考文献
Page; Tarbell
Journal of the American Chemical Society, 1953 , vol. 75, p. 2053
反应条件
1: sulfuric acid / 2 h / 20 °C
2: lithium borohydride / 1,4-dioxane / 6.5 h / 100 °C / |Inert atmosphere
3: sulfuric acid / 36 h / |Reflux
View Scheme
参考文献
Zhao, Jin; Dong, Hong-Bo; Yang, Ming-Yan; Du, Juan; Jiang, Jia-Zheng; Wang, Ming-An
Journal of Asian Natural Products Research, 2014 , vol. 16, # 3 p. 312 - 317
反应条件
TMS-OEt-acetylene in dichloromethane
T=40°C; 36 h;
参考文献
Kita, Yasuyuki; Akai, Shuji; Ajimura, Naomi; Yoshigi, Mayumi; Tsugoshi, Teruhisa; et al.
Journal of Organic Chemistry, 1986 , vol. 51, # 22 p. 4150 - 4158
反应条件
1: 65.6 percent / NaCl, AlCl3 / 2 h / 160 °C
2: Zn, HgCl2, aq.HCl / methanol / 10 h / Heating
View Scheme
参考文献
Subba Rao; Hariprakasha; Girija; Vijaya Bhaskar
Journal of the Indian Chemical Society, 1997 , vol. 74, # 11-12 p. 961 - 969
反应条件
1: 94 percent / conc. H2SO4 / 0.5 h / Ambient temperature
2: 1.) ClCOOC2H5/N(C2H5)3, 2.) NaBH4
View Scheme
参考文献
Arth, Christoph; Clemens, Martina; Meise, Werner
Liebigs Annalen der Chemie, 1994 , # 3 p. 259 - 264
