(3,4-二甲氧基苯基)丙酮合成路线 （共 58 条）
参考文献
Chemische Berichte, , vol. 77/79, p. 516,519
参考文献
Gazzetta Chimica Italiana, , vol. 36 I, p. 299
反应条件
1.1: N-benzyl-trimethylammonium hydroxide; sodium hydroxide / methanol / 6.25 h / 10 - 60 °C 2.1: N-bromosuccinmide / ethyl acetate / 3 h / 0 - 5 °C 3.1: toluene-4-sulfonic acid / toluene / 24 h / |Dean-Stark; |Reflux 4.1: n-hexyl lithium / toluene; hexane / 0.5 h / -40 °C 4.2: 1.5 h / -40 - 0 °C 5.1: hydrogenchloride; acetic acid / water / 1 h / 20 °C 5.2: 0.5 h / |Reflux 5.3: 1.5 h / 20 °C View Scheme
参考文献
Samu, Erika Molnarne; Lukacs, Gyula; Volk, Balazs; Simig, Gyula
Heterocycles, 2014 , vol. 88, # 1 p. 287 - 295
参考文献
Stein et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 700,702
反应条件
1: sodium tetrahydroborate / ethanol / 0.5 h / 20 °C 2: dihydrogen peroxide; NH4Br / acetic acid / 4 h / 20 °C 3: pyridine / 20 h / 20 °C 4: sodium hydride / mineral oil; N,N-dimethyl-formamide / 24 h / 20 °C / |Inert atmosphere 5: copper(I) bromide / N,N-dimethyl-formamide / 18 h / |Reflux View Scheme
参考文献
Cabrera, Elvia V.; Marrugo, Kelly P.; Ortega, Jose G.; Banerjee, Ajoy K.; Sanchez, Jennifer L.
Organic Preparations and Procedures International, 2012 , vol. 44, # 5 p. 455 - 459,5
Title/Abstract Full Text Show Details
Cabrera, Elvia V.; Marrugo, Kelly P.; Ortega, Jose G.; Banerjee, Ajoy K.; Sanchez, Jennifer L.
Organic Preparations and Procedures International, 2012 , vol. 44, # 5 p. 455 - 459
反应条件
(i) MCPBA, (ii) aq. KOH; Multistep reaction;
参考文献
Manitto,P. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1975 , p. 1548 - 1551
反应条件
1: 73 percent / TiCl4; Zn / tetrahydrofuran / 3 h / Heating 2: triethyl orthoformate; benzoic acid / 100 - 180 °C 3: 100 percent / H2 / PtO2 / ethyl acetate / 2.5 h View Scheme
参考文献
Gezginci, Mikail H; Timmermann, Barbara N
Tetrahedron Letters, 2001 , vol. 42, # 35 p. 6083 - 6085
反应条件
Rhodococcus ruber alcohol dehydrogenase; nicotinamide adenine dinucleotide; isopropyl alcohol; magnesium chloride in aq. phosphate buffer T=30°C; pH=7; 48 h; Inert atmosphereSchlenk techniqueEnzymatic reaction; Catalytic behavior; Reagent/catalystTime; enantioselective reaction;
参考文献
Simon, Robert C.; Busto, Eduardo; Richter, Nina; Belaj, Ferdinand; Kroutil, Wolfgang
European Journal of Organic Chemistry, 2014 , vol. 2014, # 1 p. 111 - 121
反应条件
toluene-4-sulfonic acid in toluene 12 h; Heating;
参考文献
Pongo, Laszlo; Agai, Bela; Faigl, Ferenc; Reiter, Jozsef; Simig, Gyula
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1539 - 1548
反应条件
1: 92 percent / NaH / tetrahydrofuran / 1.) 0 deg C to room temperature, 30 min, 2.) 0 deg C, 1 h; room temperature, 4 h
2: 202 mg / t-BuOK / tetrahydrofuran / 1.) 30 min, 2.) 3 d
3: 86 percent / p-TsOH / 2 h / Heating
4: 1.) cerium chloride, 2.) 2percent HCl / 1.) THF, room temperature, 4 h, 2.) 20 min
5: 52 percent / BF3*Et2O / CH2Cl2 / 24 h / Heating
View Scheme
参考文献
Majetich, George; Liu, Shuang; Fang, Jing; Siesel, David; Zhang, Yong
Journal of Organic Chemistry, 1997 , vol. 62, # 20 p. 6928 - 6951
