(3,4-二甲氧基苯基)丙酮合成路线 （共 58 条）
反应条件
glucose dehydrogenase; (R)-alanine; D-glucose; nicotinamide adenine dinucleotide; lactate dehydrogenase in aq. phosphate buffer; dimethyl sulfoxide
T=30°C; pH=7; Enzymatic reaction; enantioselective reaction;
参考文献
Orden, Alejandro A.; Schrittwieser, Joerg H.; Resch, Verena; Mutti, Francesco G.; Kroutil, Wolfgang
Tetrahedron Asymmetry, 2013 , vol. 24, # 12 p. 744 - 749
反应条件
1: in methanol
T=20°C; 0.5 h;
2: With hydrogenchloride; sodium cyanoborohydride in methanol
T=20°C; pH=4 - 6; 72 h; Further stages.;
参考文献
Montgomery; Buon; Eibauer; Guiry; Keenan; McBean
British Journal of Pharmacology, 2007 , vol. 152, # 7 p. 1121 - 1130
反应条件
sodium cyanoborohydride in methanol
72 h;
参考文献
Stout, David M.; Gorczynski, Richard J.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 326 - 328
反应条件
1: 79 percent / ammonium acetate, AcOH / benzene / 21 h / Heating
2: 2.) 6N NaOH / 1.) EtOH, reflux, 22 h, 2.) EtOH, H2O, reflux, 24 h
3: 72 percent / 6 h / Heating
View Scheme
参考文献
Nichols, David E.; Jacob, James N.; Hoffman, Andrew J.; Kohli, Jai D.; Glock, Dana
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1701 - 1705
反应条件
3-chloro-benzenecarboperoxoic acid
参考文献
Manitto,P. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1975 , p. 1548 - 1551
反应条件
sodium hydroxide; DCN in water; acetonitrile
IrradiationpH = 10; Yield given;
参考文献
Pandey, G.; Krishna, A.; Bhalerao, U.T.
Tetrahedron Letters, 1989 , vol. 30, # 14 p. 1867 - 1870
反应条件
ammonium acetate; acetic acid
2 h; Heating;
参考文献
Goel, Atul; Agarwal, Nidhi; Singh, Fateh V.; Sharon, Ashoke; Tiwari, Priti; Dixit, Manish; Pratap, Ramendra; Srivastava, Arvind K.; Maulik, Prakas R.; Ram, Vishnu J.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1089 - 1092
反应条件
sodium hydride in tetrahydrofuran
T=0 - 20°C; 2 h; Inert atmosphereSchlenk technique;
参考文献
Joshi, Tanmaya; Pierroz, Vanessa; Mari, Cristina; Gemperle, Lea; Ferrari, Stefano; Gasser, Gilles
Angewandte Chemie - International Edition, 2014 , vol. 53, # 11 p. 2960 - 2963
Angew. Chem., 2014 , vol. 53-126, # 11 p. 3004 - 3007
