6-氯-2,3-二氢-咪唑并[2,1-b]噻唑-5-羧酸合成路线 （共 4 条）
反应条件
sodium hydroxide in methanol
5 h; Heating;
参考文献
Andreani; Bonazzi; Rambaldi; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 3 p. 271 - 274
反应条件
1: 1.) conc. H2SO4; 2.) 32 percent NH4OH / 1.) 40 deg C, 2 h; 2.) ice
2: 2 N NaOH / methanol / 5 h / Heating
View Scheme
参考文献
Andreani; Bonazzi; Rambaldi; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 3 p. 271 - 274
反应条件
1: SOCl2
2: 1.) conc. H2SO4; 2.) 32 percent NH4OH / 1.) 40 deg C, 2 h; 2.) ice
3: 2 N NaOH / methanol / 5 h / Heating
View Scheme
参考文献
Andreani; Bonazzi; Rambaldi; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 3 p. 271 - 274
反应条件
1: aq. hydroxylamine hydrochloride, 32 percent NH4OH / ethanol / 0.17 h / Heating
2: SOCl2
3: 1.) conc. H2SO4; 2.) 32 percent NH4OH / 1.) 40 deg C, 2 h; 2.) ice
4: 2 N NaOH / methanol / 5 h / Heating
View Scheme
参考文献
Andreani; Bonazzi; Rambaldi; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 3 p. 271 - 274
