2,4-二羟基-5,6-二甲基烟酸乙酯合成路线 （共 6 条）
反应条件
sodium ethanolate in ethanol T=140°C; 9 h; Parr bomb;
参考文献
Seeman, Jeffrey I.; Secor, Henry V.; Chavdarian, Charles G.; Sanders, Edward B.; Bassfield, Ronald L.; Whidby, Jerry F.
Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3040 - 3048
反应条件
ethanol; sodium ethanolate T=150°C;
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 63, p. 231,236
反应条件
1: 69 percent / phosphorus oxychloride / 6 h / 120 °C / Parr bomb 2: 75 percent / H2, palladium chloride, CH3COONa / ethanol / 22 h / 2585.7 Torr View Scheme
参考文献
Seeman, Jeffrey I.; Secor, Henry V.; Chavdarian, Charles G.; Sanders, Edward B.; Bassfield, Ronald L.; Whidby, Jerry F.
Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3040 - 3048
反应条件
1: aqueous KOH-solution 2: phosphoryl chloride View Scheme
参考文献
Wibaut; Kooyman
Recueil des Travaux Chimiques des Pays-Bas, 1944 , vol. 63, p. 231,236
反应条件
1: aqueous KOH-solution 2: phosphoryl chloride 3: palladium; potassium acetate; methanol / Hydrogenation View Scheme
参考文献
Wibaut; Kooyman
Recueil des Travaux Chimiques des Pays-Bas, 1944 , vol. 63, p. 231,236
反应条件
1.1: NaOH / H2O / 2 h / Heating
1.2: 99 percent / HCl / H2O / 12 h / 20 °C / pH 7
2.1: POBr3 / dimethylformamide / 0.75 h / 110 °C
3.1: 12.70 g / Ag2CO3 / CHCl3 / 24 h / 50 °C
View Scheme
参考文献
McElroy, William T.; DeShong, Philip
Organic Letters, 2003 , vol. 5, # 25 p. 4779 - 4782
