5,6,7,8-四氢-8-氧代-2-萘甲腈合成路线 （共 4 条）
反应条件
NiCl2((PPh3)P)2; triphenylphosphine; zinc in acetonitrile
T=70°C; 4 h; Inert atmosphere;
参考文献
BARBOSA, Joseph; CARSON, Kenneth Gordon; GARDYAN, Michael Walter; HEALY, Jason Patrick; HAN, Qiang; MABON, Ross; PABBA, Praveen; TARVER, JR., James; TERRANOVA, Kristen M.; TUNOORI, Ashok; XU, Xiaolian
Patent: US2012/302562 A1, 2012 ;
Location in patent: Page/Page column 18 ;
US 20120302562 A1
反应条件
triphenylphosphine; zinc; NiCl2((PPh3)P)2 in acetonitrile
T=60°C; 2 h;
参考文献
Ulmschneider, Sarah; Mueller-Vieira, Ursula; Mitrenga, Markus; Hartmann, Rolf W.; Oberwinkler-Marchais, Sandrine; Klein, Christian D.; Bureik, Matthias; Bernhardt, Rita; Antes, Iris; Lengauer, Thomas
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1796 - 1805
反应条件
1: 2,6-dimethylpyridine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 4.08 h / -40 - 20 °C
2: triphenylphosphine; zinc; NiCl2((PPh3)P)2 / acetonitrile / 4 h / 70 °C / Inert atmosphere
View Scheme
参考文献
BARBOSA, Joseph; CARSON, Kenneth Gordon; GARDYAN, Michael Walter; HEALY, Jason Patrick; HAN, Qiang; MABON, Ross; PABBA, Praveen; TARVER, JR., James; TERRANOVA, Kristen M.; TUNOORI, Ashok; XU, Xiaolian
Patent: US2012/302562 A1, 2012 ;
US 20120302562 A1
反应条件
1: AlCl3, aluminium chloride / toluene / 0.5 h / Reflux; Inert atmosphere
2: 2,6-dimethylpyridine / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 4.08 h / -40 - 20 °C
3: triphenylphosphine; zinc; NiCl2((PPh3)P)2 / acetonitrile / 4 h / 70 °C / Inert atmosphere
View Scheme
参考文献
BARBOSA, Joseph; CARSON, Kenneth Gordon; GARDYAN, Michael Walter; HEALY, Jason Patrick; HAN, Qiang; MABON, Ross; PABBA, Praveen; TARVER, JR., James; TERRANOVA, Kristen M.; TUNOORI, Ashok; XU, Xiaolian
Patent: US2012/302562 A1, 2012 ;
US 20120302562 A1
