3-(2,4-二氟苯氧基)丙酸合成路线 （共 5 条）
反应条件
1: With phosphorus pentachloride in dichloromethane T=20°C; 1.5 h; 2: With AlCl3, aluminium chloride in dichloromethane T=0 - 20°C; Friedel Crafts acylation;
参考文献
Angeles, Angie R.; Yang, Liping; Dai, Chaoyang; Brunskill, Andrew; Basso, Andrea D.; Siddiqui, M. Arshad
Tetrahedron Letters, 2010 , vol. 51, # 48 p. 6236 - 6239
反应条件
1: aqueous sulfuric acid; sodium nitrite / Erhitzen des Reaktionsgemisches mit Kupfer(II)-sulfat auf 180grad
2: aq. NaOH solution
View Scheme
参考文献
Finger et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 94,95, 97
反应条件
potassium tert-butylate in tetrahydrofuran
T=0 - 50°C;
参考文献
Angeles, Angie R.; Yang, Liping; Dai, Chaoyang; Brunskill, Andrew; Basso, Andrea D.; Siddiqui, M. Arshad
Tetrahedron Letters, 2010 , vol. 51, # 48 p. 6236 - 6239
参考文献
Finger et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 94,95, 97
反应条件
1: With N-benzyl-N,N,N-trimethyl-ammonium chloride
120 h; Reflux;
2: With hydrogenchloride
16 h; Reflux;
参考文献
Angeles, Angie R.; Yang, Liping; Dai, Chaoyang; Brunskill, Andrew; Basso, Andrea D.; Siddiqui, M. Arshad
Tetrahedron Letters, 2010 , vol. 51, # 48 p. 6236 - 6239
