反应条件
1: 90 percent / methanol / 3 h / Heating 2: 78 percent / t-BuOK / dimethylformamide / 1 h / -10 °C 3: 96 percent / H2, glac. AcOH / 10percent Pd/C / ethanol; H2O / 0.5 h / 2585.7 Torr / Ambient temperature 4: 99 percent / glac. AcOH, sodium cyanoborohydride / 3 h / Ambient temperature View Scheme
参考文献
Bromidge, Steven M.; Dabbs, Steven; Davies, David T.; Duckworth, D. Malcolm; Forbes, Ian T.; Ham, Peter; Jones, Graham E.; King, Frank D.; Saunders, Damian V.; Starr, Susannah; Thewlis, Kevin M.; Wyman, Paul A.; Blaney, Frank E.; Naylor, Christopher B.; Bailey, Fiona; Blackburn, Thomas P.; Holland, Vicky; Kennett, Guy A.; Riley, Graham J.; Wood, Martyn D.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 10 p. 1598 - 1612
