2-氯-5-硝基三氟甲苯合成路线 （共 53 条）
反应条件
1: 92 percent / benzyltributylammonium bromide, NaOH / 24 h / 55 °C
2: 98.8 percent / H2 / Pt
3: 66 percent / K2CO3 / Cu powder / 2 h / 160 °C
4: 87 percent / H2 / 10percent Pd/C / methanol
View Scheme
参考文献
Boltze; Backer; Kreisfeld
Arzneimittel-Forschung/Drug Research, 1982 , vol. 32, # 3 p. 183 - 186
反应条件
1: antimony (V)-chloride; chlorine / 125 °C
2: SnCl2; aqueous HCl
3: sulfuric acid; aqueous sodium nitrite solution / Behandeln der Reaktionsloesung mit Kupfer(I)-bromid
View Scheme
参考文献
McBee; Sanford
Journal of the American Chemical Society, 1950 , vol. 72, p. 4053
参考文献
Kao Corporation
Patent: US5041608 A1, 1991 ;
