4-(Boc-氨基)-1-甲基吡咯-2-羧酸合成路线 （共 25 条）
反应条件
lithium hydroxide in tetrahydrofuran; methanol T=60°C; 9 h;
参考文献
Jaramillo, David; Liu, Qi; Aldrich-Wright, Janice; Tor, Yitzhak
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8151 - 8153
反应条件
sodium hydroxide in 1,4-dioxane; methanol; 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; sodium carbonate; Petroleum ether
参考文献
Genesoft, Inc.
Patent: US6143901 A1, 2000 ;
反应条件
1: N-Methyl-4-nitropyrrole-2-carboxylic Acid Methyl Ester With hydrogen; palladium 10 on activated carbon in ethyl acetate T=20°C; 12 h; 2: di-tert-butyl dicarbonate in diethyl ether T=20°C; 2 h; 3: With sodium hydroxide in methanol; water T=60°C; 2 h;
参考文献
TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCE
Patent: WO2007/29364 A1, 2007 ;
Location in patent: Page/Page column 18-19 ;
反应条件
1: aq. Na2CO3 / dioxane / 3 h 2: aq. NaOH / methanol / 6 h / 60 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 118, # 26 p. 6141 - 6146
反应条件
1: 91 percent / CH2Cl2 / 24 h 2: 81 percent / N-bromosuccinimide / CH2Cl2 / 18 h / -10 - 20 °C 3: 93 percent / methanol / 1 h 4: 99 percent / K3PO4; N,N'-dimethylethylenediamine / CuI / dioxane / 48 h / 110 °C 5: 94 percent / LiOH / tetrahydrofuran; methanol / 9 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 8151 - 8153
反应条件
1: 81 percent / N-bromosuccinimide / CH2Cl2 / 18 h / -10 - 20 °C 2: 93 percent / methanol / 1 h 3: 99 percent / K3PO4; N,N'-dimethylethylenediamine / CuI / dioxane / 48 h / 110 °C 4: 94 percent / LiOH / tetrahydrofuran; methanol / 9 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 8151 - 8153
反应条件
1: 99 percent / K3PO4; N,N'-dimethylethylenediamine / CuI / dioxane / 48 h / 110 °C 2: 94 percent / LiOH / tetrahydrofuran; methanol / 9 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 8151 - 8153
反应条件
1: 93 percent / methanol / 1 h 2: 99 percent / K3PO4; N,N'-dimethylethylenediamine / CuI / dioxane / 48 h / 110 °C 3: 94 percent / LiOH / tetrahydrofuran; methanol / 9 h / 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 23 p. 8151 - 8153
反应条件
1: H2, 1.0 M Na2CO3(aq.) / 5percent Pd/C / 3.5 h / 3102.9 Torr / Ambient temperature 2: tetrahydrofuran; diethyl ether / 1.) 1 h, ice cooled, 2.) 2 h, ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 17 p. 3492 - 3497
反应条件
1: 69 percent / 2 M NaOH / ethanol / 1.5 h / Heating 2: H2, 1.0 M Na2CO3(aq.) / 5percent Pd/C / 3.5 h / 3102.9 Torr / Ambient temperature 3: tetrahydrofuran; diethyl ether / 1.) 1 h, ice cooled, 2.) 2 h, ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 17 p. 3492 - 3497
