反应条件
1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide (EDC) / dimethylformamide / 40 °C
2: H2 / 15percent Pd/C / dimethylformamide / 2 h / 3102.9 Torr / Ambient temperature
3: DCC / dimethylformamide / 1.) 0 deg C, 1h, 2.) 40 deg C, overnight
4: NaHCO3 / dioxane; H2O / 1.) RT, 1 h, 2.) 40 deg C, 2 h
View Scheme
参考文献
Grehn; Ragnarsson; Eriksson; Oberg
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 1042 - 1049
