6-(叔丁基二甲基硅氧基)己酸合成路线 （共 18 条）
反应条件
1: 89 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene
2: 100 percent / NaOH / tetrahydrofuran; methanol; H2O
View Scheme
参考文献
Franklin, Christopher L.; Li, Hui; Martin, Stephen F.
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7298 - 7307
反应条件
1: imidazole / dimethylformamide / 26 h / Ambient temperature
2: NaOH / dimethylformamide; methanol; H2O / 13 h
View Scheme
参考文献
Aristoff, Paul A.; Johnson, Paul D.; Harrison, Allen W.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5341 - 5348
反应条件
1: triethylamine / dichloromethane / 20 °C
2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / |Inert atmosphere
3: 10 Pd/C; hydrogen / ethyl acetate / 2 h / 20 °C
View Scheme
参考文献
Zhu, Hua; Yang, Zhi; Li, Nan; Wang, Xue-Juan; Wang, Feng; Su, Hua; Xie, Qing; Zhang, Yan; Ma, Yun-Xia; Lin, Bao-He
Journal of Organometallic Chemistry, 2012 , vol. 716, p. 95 - 102
反应条件
1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere
2: methanol; N-benzyl-trimethylammonium hydroxide / 1 h / 20 °C
View Scheme
参考文献
Su, Meng; Wang, Jie; Tang, Xinjing
Chemistry - A European Journal, 2012 , vol. 18, # 31 p. 9628 - 9637
反应条件
1H-imidazole; hydrogenchloride; methanol; sodium hydroxide
1.) reflux, 2.) DMF, 3.) THF-CH3OH-H2O; Multistep reaction;
参考文献
Rastetter, William H.; Phillion, Dennis P.
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3209 - 3214
反应条件
1: DMAP; DCC / CH2Cl2 / 24 h / 20 °C
2: TBAF / tetrahydrofuran / 48 °C
View Scheme
参考文献
Hum, Gabriel; Wooler, Krista; Lee, Jeremy; Taylor, Scott D.
Canadian Journal of Chemistry, 2000 , vol. 78, # 5 p. 642 - 655
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; 0.0833333 h; Inert atmosphere;
参考文献
Hardee, David J.; Kovalchuke, Lyudmila; Lambert, Tristan H.
Journal of the American Chemical Society, 2010 , vol. 132, # 14 p. 5002 - 5003
反应条件
1: 1.) DCC, DMAP; 2.) CH3COOH / 1.) THF, -25 deg C, 4 days; 2.) H2O, room temp., 8 h
2: 24 percent Chromat. / t-BuOK / benzene; tetrahydrofuran
View Scheme
参考文献
Rastetter, William H.; Phillion, Dennis P.
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3209 - 3214
