(1S,4R)-4-氨基-环戊-2-烯基-1-甲酸甲酯盐酸盐合成路线 （共 7 条）
反应条件
hydrogenchloride T=20°C; 24 h;
参考文献
Wang, Zhiyong; Silverman, Richard B.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 7 p. 2242 - 2252
反应条件
lithium triethylborohydride in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
Kam, Bernard L.; Oppenheimer, Norman J.
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3268 - 3272
反应条件
pyridine
1 h; Ambient temperature; Yield given;
参考文献
Ikbal; Cerceau; Le Goffic; Sicsic
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 415 - 420
反应条件
pyridine
1 h; Ambient temperature; Yield given;
参考文献
Ikbal; Cerceau; Le Goffic; Sicsic
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 415 - 420
反应条件
1: 95 percent / Lithium triethylborohydride / tetrahydrofuran / 0.5 h / 0 °C
2: pyridine
View Scheme
参考文献
Kam, Bernard L.; Oppenheimer, Norman J.
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3268 - 3272
反应条件
Multi-step reaction with 4 steps 1: pyridine / 1 h / Ambient temperature3: OsO4, NMMO / 2-methyl-propan-2-ol; H2O / Ambient temperature4: 1.) LiBH(Et)3; 2.) 6N HCl / 1.) THF; 2.) reflux
参考文献
Ikbal; Cerceau; Le Goffic; Sicsic European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 415 - 420
反应条件
Multi-step reaction with 2 steps 1: pyridine / 1 h / Ambient temperature2: H2O / pig liver esterase
参考文献
Ikbal; Cerceau; Le Goffic; Sicsic European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 415 - 420
