5-硝基-1H-异色烯-1-酮合成路线 （共 16 条）
反应条件
1: 86.6 percent / TiCl3 / acetic acid; H2O / 0.12 h 2: 97.6 percent / sodium / methanol / 0.25 h / Heating View Scheme
参考文献
Somei; Karasawa; Shoda; Kaneko
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 1 p. 249 - 253
反应条件
1: 99 percent / H2, aq. HCl / 10 percent Pd/C / tetrahydrofuran / 6 h 2: 35 percent / NaNO2, aq. H2SO4, KBr, CuBr / 2 h / 5 °C View Scheme
参考文献
Parveen, Ifat; Naughton, Declan P.; Whish, William J. D.; Threadgill, Michael D.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 14 p. 2031 - 2036
参考文献
Rehwinkel, Hartmut; Baeurle, Stefan; Berger, Markus; Schmees, Norbert; Schaecke, Heike; Krolikiewicz, Konrad; Mengel, Anne; Nguyen, Duy; Jaroch, Stefan; Skuballa, Werner
Patent: US2005/131226 A1, 2005 ;
Location in patent: Page/Page column 8 ;
反应条件
1: 62.8 percent / LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature 2: 24 percent / TiCl3 / 0.12 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 17, p. 417 - 423
反应条件
1: 99 percent / H2, aq. HCl / 10 percent Pd/C / tetrahydrofuran / 6 h 2: 35 percent / NaNO2, aq. H2SO4, KBr, CuBr / 2 h / 5 °C 3: 71 percent / NH3 / 2-methoxy-ethanol / 8 h / Heating View Scheme
参考文献
Parveen, Ifat; Naughton, Declan P.; Whish, William J. D.; Threadgill, Michael D.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 14 p. 2031 - 2036
反应条件
in DMF (N,N-dimethyl-formamide)
T=130°C; 12 h;
参考文献
SCHERING AKTIENGESELLSCHAFT
Patent: WO2005/34939 A1, 2005 ;
Location in patent: Page/Page column 56 ;
反应条件
1,1-dimethoxyethane; N,N-dimethyl-formamide in N,N-dimethyl-formamide
T=110 - 120°C; 7 h;
参考文献
Matsui; Sugiura; Nakai; Iguchi; Shigeoka; Takada; Odagaki; Nagao; Ushio; Ohmoto; Iwamura; Yamazaki; Arai; Kawamura
Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3307 - 3319
反应条件
in DMF (N,N-dimethyl-formamide)
T=130°C; 12 h;
参考文献
Rehwinkel, Hartmut; Baeurle, Stefan; Berger, Markus; Schmees, Norbert; Schaecke, Heike; Krolikiewicz, Konrad; Mengel, Anne; Nguyen, Duy; Jaroch, Stefan; Skuballa, Werner
Patent: US2005/222154 A1, 2005 ;
Location in patent: Page/Page column 15 ;
US 20050222154 A1
反应条件
silica gel in ethyl acetate
T=20°C; 1 - 3 h; Product distribution / selectivity;
参考文献
Kelly, Michael G.; Kincaid, John; Fang, Yunfeng; He, Jianhua; Cao, Yeyu; Kaub, Carl; Gowlugari, Sumithra; Wang, Zhan
Patent: US2007/225324 A1, 2007 ;
Location in patent: Page/Page column 19; 22; 24-25 ;
反应条件
in N,N-dimethyl-formamide
22 h; Heating;
参考文献
Somei, Masanori; Shoda, Toshiya
Heterocycles, 1982 , vol. 17, p. 417 - 423
