戊-4-炔基对甲苯磺酸酯合成路线 （共 17 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine Inert atmosphere;
参考文献
Caldarelli, Sergio A.; El Fangour, Siham; Wein, Sharon; Tran Van Ba, Christophe; Perigaud, Christian; Pellet, Alain; Vial, Henri J.; Peyrottes, Suzanne
Journal of Medicinal Chemistry, 2013 , vol. 56, # 2 p. 496 - 509
反应条件
pyridine in dichloromethane T=0 - 20°C;
参考文献
Zammit, Steven C.; Cox, Alison J.; Gow, Renae M.; Zhang, Yuan; Gilbert, Richard E.; Krum, Henry; Kelly, Darren J.; Williams, Spencer J.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 7003 - 7006
反应条件
1: 85 percent / lithium aluminium hydride / diethyl ether / 2 h / Heating 2: pyridine View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1215 - 1224
反应条件
1: ethanol 2: aqueous KOH-solution 3: 160 °C / 18 Torr 4: sulfuric acid View Scheme
参考文献
Journal of the Chemical Society, , p. 3052,3055
反应条件
C29H40ClCuN2; sodium t-butanolate; tert-butyl alcohol in tetrahydrofuran; hexane T=40°C; 20 h; Inert atmosphere; chemoselective reaction;
参考文献
Semba, Kazuhiko; Fujihara, Tetsuaki; Xu, Tinghua; Terao, Jun; Tsuji, Yasushi
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 8 p. 1542 - 1550
反应条件
lithium bromide in acetone 17 h; Heating;
参考文献
Shi, L.; Narula, C. K.; Mak, K. T.; Kao, L.; Xu, Y.; Heck, R. F.
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 3894 - 3900
反应条件
1: ethanol 2: aqueous KOH-solution 3: 160 °C / 18 Torr View Scheme
参考文献
Eglinton; Whiting
Journal of the Chemical Society, 1953 , p. 3052,3055
反应条件
1: NaCN / dimethylsulfoxide / 0.5 h / 70 °C 2: KOH / ethanol; H2O / 4 h / Heating View Scheme
参考文献
Gerlach, Hans; Kuenzler, Peter
Helvetica Chimica Acta, 1980 , vol. 63, # 8 p. 2312 - 2319
反应条件
1: acetoacetic acid methyl ester With sodium hydride; potassium iodide in tetrahydrofuran; N,N-dimethyl-formamide T=0 - 20°C; 2: 4-pentynyl tosylate in tetrahydrofuran; N,N-dimethyl-formamide T=20 - 100°C;
参考文献
Deng, Chen-Liang; Song, Ren-Jie; Liu, Yi-Lin; Li, Jin-Heng
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 18 p. 3096 - 3100
反应条件
sodium cyanide in dimethyl sulfoxide T=70°C; 0.5 h; Yield given;
参考文献
Gerlach, Hans; Kuenzler, Peter
Helvetica Chimica Acta, 1980 , vol. 63, # 8 p. 2312 - 2319
