1.1: 1-methyl-pyrrolidin-2-one / 24 h / 170 °C
1.2: celite / 1 h / 80 °C
2.1: triethylamine / tetrahydrofuran / 15 - 20 °C
3.1: sodium hydroxide; water / 1 h / 90 °C
3.2: 70 °C
3.3: 20 °C / pH 3 - 4
4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 20 °C
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参考文献
SHANGHAI DE NOVO PHARMATECH CO LTD.; Gao, Daxin
Patent: US2013/224107 A1, 2013 ;