4-氯-6-氟喹啉-3-甲酸乙酯合成路线 （共 8 条）
反应条件
1: With trichlorophosphate T=100°C; 0.5 h; 2: With ammonia in water T=0°C;
参考文献
BIOLIPOX AB
Patent: WO2007/51982 A1, 2007 ;
Location in patent: Page/Page column 43-44 ;
反应条件
thionyl chloride 3 h; Heating / reflux;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2004/69792 A2, 2004 ;
Location in patent: Page 168 ;
反应条件
1: pyridine / toluene / 2 h / Heating 2: diphenyl ether / 1 h / 250 °C 3: 0.995 g / thionyl chloride / 1 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 21 p. 6351 - 6363
反应条件
1: diphenyl ether / 1 h / 250 °C 2: 0.995 g / thionyl chloride / 1 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 21 p. 6351 - 6363
反应条件
1: pyridine / toluene / 2 h / Heating 2: diphenyl ether / 1 h / 250 °C 3: 0.995 g / thionyl chloride / 1 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 21 p. 6351 - 6363
反应条件
1: |Reflux 2: trichlorophosphate / |Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 11 p. 4811 - 4815
反应条件
hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10 on activated carbon in ethanol
P=760.051 - 2585.81 Torr; 26 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2004/69792 A2, 2004 ;
Location in patent: Page 168-169 ;
参考文献
Savini; Chiasserini; Pellerano; Biggio; Maciocco; Serra; Cinone; Carrieri; Altomare; Carotti
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 2 p. 431 - 444
