1: 27 percent / K2CO3 / dimethylsulfoxide / 39 h / Ambient temperature 2: 87 percent / ethanol; H2O / 15 h / Ambient temperature View Scheme
参考文献
Kelley, James L.; Krochmal, Mark P.; Linn, James A.; McLean, Ed W.; Soroko, Francis E.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 606 - 612
1: With sodium hydroxide; sodium tetrahydroborate; cobalt(II) chloride in tetrahydrofuran; water T=0 - 55°C; 4.33 h; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
TANABE SEIYAKU CO., LTD.
Patent: WO2006/30984 A1, 2006 ;
Location in patent: Page/Page column 63-64; 134 ;
WO 2006/030984 A1