(R)-1-(4-苄氧基苯基)-4-苄基-6-羟基甲基-2-哌嗪酮合成路线 （共 3 条）
反应条件
sodium hydroxide in tetrahydrofuran; methanol
T=20°C; 18 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2004/89915 A1, 2004 ;
Location in patent: Page 59; 61 ;
反应条件
1: 94 percent / K2CO3 / tetrahydrofuran / 6 h / 20 °C
2: 93 percent / tetrahydrofuran / 18 h / Heating
3: MgSO4 / methanol; CH2Cl2 / 72 h / 35 °C
4: aq. NaOH / methanol / 0.33 h / 0 °C
5: NaH / dimethylformamide / 0 - 50 °C
View Scheme
参考文献
Powell, Noel A.; Ciske, Fred L.; Clay, Emma C.; Cody, Wayne L.; Downing, Dennis M.; Blazecka, Peter G.; Holsworth, Daniel D.; Edmunds, Jeremy J.
Organic Letters, 2004 , vol. 6, # 22 p. 4069 - 4072
反应条件
1: MgSO4 / methanol; CH2Cl2 / 72 h / 35 °C
2: aq. NaOH / methanol / 0.33 h / 0 °C
3: NaH / dimethylformamide / 0 - 50 °C
View Scheme
参考文献
Powell, Noel A.; Ciske, Fred L.; Clay, Emma C.; Cody, Wayne L.; Downing, Dennis M.; Blazecka, Peter G.; Holsworth, Daniel D.; Edmunds, Jeremy J.
Organic Letters, 2004 , vol. 6, # 22 p. 4069 - 4072
