4-氰基-3-硝基三氟甲基苯合成路线 （共 30 条）
参考文献
Hauptschein et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 1051,1054
反应条件
potassium fluoride; polymethylhydrosiloxane; palladium diacetate in tetrahydrofuran T=20°C; 0.5 h;
参考文献
Synthesis, , # 19 p. 3316 - 3340
反应条件
aceton-washed saccharomyces cerevisiae in water; dimethyl sulfoxide T=32°C;
参考文献
Blackie, Josie A.; Turner, Nicholas J.; Wells, Andrew S.
Tetrahedron Letters, 1997 , vol. 38, # 17 p. 3043 - 3046
反应条件
diisobutylaluminium hydride in benzene T=25°C; 2 h;
参考文献
Lewandowska, Elzbieta; Kinastowski, Stefan; Wnuk, Stanislaw F.
Canadian Journal of Chemistry, 2002 , vol. 80, # 2 p. 192 - 199
反应条件
1: aqueous H2SO4 / 165 °C 2: iron-powder; aqueous NH4Cl View Scheme
参考文献
Suez, Gal; Bloch, Victoria; Nisnevich, Gennady; Gandelman, Mark
European Journal of Organic Chemistry, 2012 , # 11 p. 2118 - 2122
反应条件
sodium methylate in methanol; water
参考文献
E.I. DU PONT DE NEMOURS AND COMPANY
Patent: EP386892 A3, 1990 ;
反应条件
potassium fluoride; polymethylhydrosiloxane; palladium diacetate in tetrahydrofuran T=20°C; 0.5 h;
参考文献
Synthesis, , # 19 p. 3316 - 3340
反应条件
1: 2-nitro-4-(trifluoromethyl)benzene-carbonitrile With iron(III) chloride; hydrazine hydrate in methanol; water 3 h; Heating; 2: formic acid With hydrogenchloride in water T=90 - 130°C; Further stages.;
参考文献
Chandregowda, Venkateshappa; Venkateswara Rao, Gudapati; Chandrasekara Reddy, Goukanapalli
Heterocycles, 2007 , vol. 71, # 1 p. 39 - 48
反应条件
1: aq. H2SO4
View Scheme
参考文献
Szczecinski, Przemyslaw; Gryff-Keller, Adam; Molchanov, Sergey
Journal of Organic Chemistry, 2006 , vol. 71, # 12 p. 4636 - 4641
反应条件
1: hydrogen bromide / Inert atmosphere
2: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C / 3800.26 Torr
3: 4 h / 160 - 180 °C / Inert atmosphere
4: phosphorus pentachloride; trichlorophosphate / 4 h / Reflux; Inert atmosphere
View Scheme
参考文献
Suez, Gal; Bloch, Victoria; Nisnevich, Gennady; Gandelman, Mark
European Journal of Organic Chemistry, 2012 , # 11 p. 2118 - 2122
