1: (S)-alpha-methylbenzyl alcohol With pyridine; phosphorus tribromide in diethyl ether T=-20 - 0°C; 2: sodium cyanide in N,N-dimethyl-formamide T=80°C; 3: With hydrogenchloride in dichloromethane Heating; Title compound not separated from byproducts;
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 44, # 3 p. 557 - 562
Candida antarctica lipase A wild type in acetonitrile T=20°C; 2 h; aq. phosphate bufferaq. bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 132, # 20 p. 7038 - 7042
tris(hydroxymethyl)methylamine hydrochloride T=35°C; 168 h; lipase C andida rugosa type VII immobilized on alumina, pH 8.5;
参考文献
Sinisterra, Jose Vicente; Llama, Emilio Fidel; Campo, Carmen del; Cabezas, Maria Jose; Moreno, Jose Maria; Arroyo, Miguel
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1994 , # 6 p. 1333 - 1336
