(S)-(-)-N-BOC-L-脯氨酸肼合成路线 （共 7 条）
反应条件
in chloroform
T=-15°C; 1 h;
参考文献
Vidal, Joelle; Guy, Laure; Sterin, Sebastien; Collet, Andre
Journal of Organic Chemistry, 1993 , vol. 58, # 18 p. 4791 - 4793
反应条件
N-benzyl-trimethylammonium hydroxide
1.) MeOH, 30 min, 2.) CHCl3, -30 deg C, 1 h;
参考文献
Vidal, Joelle; Damestoy, Stephanie; Guy, Laure; Hannachi, Jean-Christophe; Aubry, Andre; Collet, Andre
Chemistry - A European Journal, 1997 , vol. 3, # 10 p. 1691 - 1709
反应条件
1: 92 percent / diethyl ether
2: 75 percent / toluene / 17 h / Heating
3: LiMCPBA / CH2Cl2 / 2 h / -78 °C
4: 95 percent / benzyltrimethylammonium hydroxyde / 1.) MeOH, 30 min, 2.) CHCl3, -30 deg C, 1 h
View Scheme
参考文献
Vidal, Joelle; Damestoy, Stephanie; Guy, Laure; Hannachi, Jean-Christophe; Aubry, Andre; Collet, Andre
Chemistry - A European Journal, 1997 , vol. 3, # 10 p. 1691 - 1709
反应条件
1: 75 percent / toluene / 17 h / Heating
2: LiMCPBA / CH2Cl2 / 2 h / -78 °C
3: 95 percent / benzyltrimethylammonium hydroxyde / 1.) MeOH, 30 min, 2.) CHCl3, -30 deg C, 1 h
View Scheme
参考文献
Vidal, Joelle; Damestoy, Stephanie; Guy, Laure; Hannachi, Jean-Christophe; Aubry, Andre; Collet, Andre
Chemistry - A European Journal, 1997 , vol. 3, # 10 p. 1691 - 1709
反应条件
1: LiMCPBA / CH2Cl2 / 2 h / -78 °C
2: 95 percent / benzyltrimethylammonium hydroxyde / 1.) MeOH, 30 min, 2.) CHCl3, -30 deg C, 1 h
View Scheme
参考文献
Vidal, Joelle; Damestoy, Stephanie; Guy, Laure; Hannachi, Jean-Christophe; Aubry, Andre; Collet, Andre
Chemistry - A European Journal, 1997 , vol. 3, # 10 p. 1691 - 1709
反应条件
sodium hydrogencarbonate
参考文献
Hetenyi, Anasztazia; Toth, Gabor K.; Somlai, Csaba; Vass, Elemer; Martinek, Tamas A.; Fueloep, Ferenc
Chemistry - A European Journal, 2009 , vol. 15, # 41 p. 10736 - 10741
反应条件
1: tetrahydrofuran; diethyl ether / 0 °C
2: aq. HCl / dioxane / 0.5 h / 20 °C
View Scheme
参考文献
Raju; Mortell, Kathleen; Anandan, Sampathkumar; O'Dowd, Hardwin; Gao, Hongwu; Gomez, Marcela; Hackbarth, Corinne; Wu, Charlotte; Wang, Wen; Yuan, Zhengyu; White, Richard; Trias, Joaquim; Patel, Dinesh V.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 14 p. 2413 - 2418
