6-氧代-1-苯基-1,6-二氢吡啶-3-甲酸合成路线 （共 7 条）
反应条件
1: With sodium hydroxide T=50°C; 3 h; 2: With hydrogenchloride
参考文献
Zhu, Weixing; Shen, Jie; Li, Qianbin; Pei, Qi; Chen, Jun; Chen, Zhuo; Liu, Zhaoqian; Hu, Gaoyun
Archiv der Pharmazie, 2013 , vol. 346, # 9 p. 654 - 666
反应条件
1: alcohol 2: NaOH-solution View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 273, p. 179
反应条件
1.1: pyridine; copper (II) acetate monohydrate / dichloromethane / 12 h / 20 °C / Molecular sieve 2.1: water; lithium hydroxide hydrate / tetrahydrofuran / 1 h / 0 °C 2.2: pH 2 View Scheme
反应条件
1.1: thionyl chloride / 6 h / 0 °C / Reflux 2.1: pyridine; copper (II) acetate monohydrate / dichloromethane / 12 h / 20 °C / Molecular sieve 3.1: water; lithium hydroxide hydrate / tetrahydrofuran / 1 h / 0 °C 3.2: pH 2 View Scheme
反应条件
1.1: ethanol 1.2: 40 - 45 °C 2.1: sodium hydroxide / 3 h / 50 °C View Scheme
参考文献
Archiv der Pharmazie, , vol. 346, # 9 p. 654 - 666
反应条件
1: pyridine / 80 °C 2: lithium hydroxide hydrate / methanol; water / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 12 p. 5079 - 5093
反应条件
1: alcohol 2: NaOH-solution View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 273, p. 179
