6-氧代-1-苯基-1,6-二氢-吡啶-3-羧酸甲酯合成路线 （共 5 条）
反应条件
pyridine; copper diacetate in dichloromethane T=20°C; 12 h; Molecular sieve;
参考文献
AUSPEX PHARMACEUTICALS, INC.; ZHANG, Chengzhi; SOMMERS, Andreas
Patent: WO2012/122165 A2, 2012 ;
Location in patent: Page/Page column 63 ;
反应条件
in N,N-dimethyl-formamide T=150°C; 10 h; Reflux;
参考文献
SK BIOPHARMACEUTICALS CO., LTD.; Maeng, Cheol Young; Jang, Young Koo; Cha, Su Bong; Shin, Hye Won; Joung, Chan Mi; Cha, Hwa Ryun; Yi, Eun Jung
Patent: US2013/317059 A1, 2013 ;
Location in patent: Paragraph 0040-0041 ;
反应条件
1: in ethanol 2: With sodium carbonate T=40 - 45°C;
参考文献
Zhu, Weixing; Shen, Jie; Li, Qianbin; Pei, Qi; Chen, Jun; Chen, Zhuo; Liu, Zhaoqian; Hu, Gaoyun
Archiv der Pharmazie, 2013 , vol. 346, # 9 p. 654 - 666
反应条件
1: thionyl chloride / 6 h / 0 °C / Reflux 2: pyridine; copper (II) acetate monohydrate / dichloromethane / 12 h / 20 °C / Molecular sieve View Scheme
反应条件
1: With sodium hydroxide T=50°C; 3 h; 2: With hydrogenchloride
参考文献
Zhu, Weixing; Shen, Jie; Li, Qianbin; Pei, Qi; Chen, Jun; Chen, Zhuo; Liu, Zhaoqian; Hu, Gaoyun
Archiv der Pharmazie, 2013 , vol. 346, # 9 p. 654 - 666
