lithium diisopropyl amide multistep reaction: 1.) THF, reflux, 1 h, 2.) -78 deg C, 2.5 h; temperature conditions effect on enatiomeric excess; enantioselective alkylation of cyclic ketones; role of (E)- ans (Z)-lithioenamines; thermodynamic and kinetic products; Product distribution;

lithium diisopropyl amide multistep reaction: 1.) THF, reflux, 1 h, 2.) -78 deg C, 2.5 h; temperature conditions effect on enatiomeric excess; enantioselective alkylation of cyclic ketones; role of (E)- ans (Z)-lithioenamines; thermodynamic and kinetic products; Product distribution;