6-苄基-2,4-二氯-5,6,7,8-四氢吡啶并[4,3-d]嘧啶合成路线 （共 6 条）
反应条件
trichlorophosphate 3 h; Inert atmosphereReflux;
参考文献
Sun, Hao-Peng; Jia, Jian-Min; Jiang, Fen; Xu, Xiao-Li; Liu, Fang; Guo, Xiao-Ke; Cherfaoui, Bahidja; Huang, Hao-Ze; Pan, Yang; You, Qi-Dong
European Journal of Medicinal Chemistry, 2014 , vol. 79, p. 399 - 412
反应条件
1: sodium methylate / methanol / 96 h / |Reflux; |Inert atmosphere 2: trichlorophosphate / 3 h / |Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 24 p. 10958 - 10971
反应条件
1: sodium methylate / ethanol / 24 h / |Reflux 2: trichlorophosphate / 3 h / |Inert atmosphere; |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 79, p. 399 - 412
反应条件
1.1: 2-chloroethoxycarbonyl chloride / dichloromethane / 1.25 h / 0 - 20 °C 1.2: 0.5 h / |Reflux 2.1: tetraalkylammonium carbonate polymer-bound resin / dichloromethane / 1 h / 20 °C View Scheme
参考文献
ZHOU, Han-Jie; PARLATI, Francesco; WUSTROW, David
Patent: WO2014/15291 A1, 2014 ;
反应条件
1-chloroethyl chlorocarbonate in 1,2-dichloro-ethane T=0 - 100°C; 6 h;
参考文献
ZHOU, Han-Jie; PARLATI, Francesco; WUSTROW, David
Patent: WO2014/15291 A1, 2014 ;
Location in patent: Page/Page column 172; 173 ;
反应条件
1-chloroethyl chlorocarbonate in 1,2-dichloro-ethane 5 h; Heating / reflux;
参考文献
EP1537879 A1, ;
Page/Page column 61-62 ;
