4-((4-乙炔苯基)乙炔)-N,N-二甲基苯胺合成路线 （共 6 条）
反应条件
sodium hydroxide in toluene
Heating;
参考文献
Rodriguez, J. Gonzalo; Lafuente, Antonio; Rubio, Laura; Esquivias, Jorge
Tetrahedron Letters, 2004 , vol. 45, # 38 p. 7061 - 7064
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
0.5 h;
参考文献
Kulhanek, Jiri; Bures, Filip; Ludwig, Miroslav
Beilstein Journal of Organic Chemistry, 2009 , vol. 5, art. no. 11
反应条件
1: 82 percent / diethylamine; copper(I) iodide / dichlorobis[triphenylphosphine]palladium
2: sodium hydroxide / toluene / Heating
3: 82 percent / copper(I) iodide; diethylamine / dichlorobis[(triphenyl)phosphine]palladium / 8 h / 20 °C
4: 90 percent / sodium hydroxide / toluene / 12 h / Heating
View Scheme
参考文献
Rodriguez, J. Gonzalo; Esquivias, Jorge; Lafuente, Antonio; Rubio, Laura
Tetrahedron, 2006 , vol. 62, # 13 p. 3112 - 3122
反应条件
1: sodium hydroxide / toluene / Heating
2: 82 percent / copper(I) iodide; diethylamine / dichlorobis[(triphenyl)phosphine]palladium / 8 h / 20 °C
3: 90 percent / sodium hydroxide / toluene / 12 h / Heating
View Scheme
参考文献
Rodriguez, J. Gonzalo; Esquivias, Jorge; Lafuente, Antonio; Rubio, Laura
Tetrahedron, 2006 , vol. 62, # 13 p. 3112 - 3122
反应条件
1: 82 percent / copper(I) iodide; diethylamine / dichlorobis[(triphenyl)phosphine]palladium / 8 h / 20 °C
2: 90 percent / sodium hydroxide / toluene / 12 h / Heating
View Scheme
参考文献
Rodriguez, J. Gonzalo; Esquivias, Jorge; Lafuente, Antonio; Rubio, Laura
Tetrahedron, 2006 , vol. 62, # 13 p. 3112 - 3122
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran
T=50°C; Sonogashira coupling; 5 h; Inert atmosphere;
参考文献
Bures, Filip; Cermakova, Hana; Kulhanek, Jiri; Ludwig, Miroslav; Kuznik, Wojciech; Kityk, Iwan V.; Mikysek, Tomas; Ruzicka, Ales
European Journal of Organic Chemistry, 2012 , # 3 p. 529 - 538
