5-溴-2-甲基-4-甲基吡啶合成路线 （共 8 条）
反应条件
1: 5-Bromo-2-chloropyridine With tert.-butyl lithium in tetrahydrofuran T=-78°C; 0.0833333 h; 2: methyl iodide in tetrahydrofuran T=-78°C;
参考文献
Pierrat, Philippe; Gros, Philippe; Fort, Yves
Synlett, 2004 , # 13 p. 2319 - 2322
反应条件
trichlorophosphate T=140°C; 2 h; Autoclaveneat (no solvent);
参考文献
Wang, Han; Wen, Kun; Wang, Le; Xiang, Ye; Xu, Xiaocheng; Shen, Yongjia; Sun, Zhihua
Molecules, 2012 , vol. 17, # 4 p. 4533 - 4544
反应条件
1: With hydrogenchloride; sodium nitrite T=-20°C; 1 h; 2: With sodium hydroxide T=0 - 5°C; pH=11;
参考文献
Cheng, Jie; Xu, Liang; Stevens, Edwin D.; Trudell, Mark L.; Izenwasser, Sari; Wade, Dean
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 4 p. 569 - 574
反应条件
1: 5-Bromo-2-chloropyridine With lithium diisopropyl amide T=-78°C; Inert atmosphere; 2: methyl iodide Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 75, # 10 p. 3224 - 3231
反应条件
1: 5-Bromo-2-chloropyridine With lithium diisopropyl amide T=-40°C; 1 h; Inert atmosphere; 2: methyl iodide T=-78 - 20°C; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 75, # 10 p. 3224 - 3231
反应条件
1.1: 70 percent / bromine; acetic acid / 3 h / 50 °C 2.1: sodium nitrite; concd. hydrochloric acid / 1 h / -20 °C 2.2: 48 percent / aq. sodium hydroxide / 0 - 5 °C / pH 11 View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 41, # 4 p. 569 - 574
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
Heating;
参考文献
Cheng, Jie; Xu, Liang; Stevens, Edwin D.; Trudell, Mark L.; Izenwasser, Sari; Wade, Dean
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 4 p. 569 - 574
反应条件
in 1-methyl-pyrrolidin-2-one
T=150°C; 0.5 h; Microwave irradiation;
参考文献
Alam, Muzaffar; Du Bois, Daisy Joe; Hawley, Ronald Charles; Kennedy-Smith, Joshua; Minatti, Ana Elena; Palmer, Wylie Solang; Silva, Tania; Wilhelm, Robert Stephen
Patent: US2011/71150 A1, 2011 ;
Location in patent: Page/Page column 35 ;
