(4R,5S)-3-丙酰基-4-甲基-5-苯基-2-噁唑烷酮合成路线 （共 9 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Tanasova, Marina; Borhan, Babak
European Journal of Organic Chemistry, 2012 , # 17 p. 3261 - 3269
反应条件
electrogenerated base from 2-pyrrolidone; N(Et)4ClO4 in acetonitrile T=20°C;
参考文献
Feroci; Inesi; Palombi; Rossi; Sotgiu
Journal of Organic Chemistry, 2001 , vol. 66, # 18 p. 6185 - 6188
反应条件
1.1: potassium carbonate / 6 h / 100 °C 1.2: methanol / 0.5 h / Heating 2.1: 98 percent / n-butyllithium / tetrahydrofuran; hexane / -78 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 45 p. 10757 - 10773
反应条件
1: 80 percent / potassium carbonate / toluene / 130 °C / Heating 2: 1.) butyllithium / 1.) THF/hexane, -78 deg C, 1 h, 2.) 1 h View Scheme
参考文献
Australian Journal of Chemistry, , vol. 43, # 6 p. 1035 - 1046
反应条件
1: 1 M methanol. KOH / 1.) 50 deg C, 3 h, 2.) reflux, 3 h 2: butyllithium / 1.) THF, hexane, RT, 0.5 h, 2.) 0.5 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 23 p. 5415 - 5421
反应条件
1: 2.) MeONa / 1.) toluene, reflux, 2.) toluene, reflux, 3 h 2: 1.) BuLi / 1.) THF, hexane, from -75 to -70 deg C, 2.) THF, hexane, from -80 to -55 deg C, 2.5 h View Scheme
参考文献
Synthesis, , # 6 p. 719 - 725
反应条件
12 h; Ambient temperaturediff. solvents (ethyl acetate, benzene); Product distribution;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1635 - 1640
反应条件
1.1: Bu2BOTf; Et3N / CH2Cl2 / -78 - 0 °C 1.2: 80 percent / aq. H2O2 / methanol; CH2Cl2 / 1 h / 0 °C 2.1: trimethylaluminum / tetrahydrofuran; toluene / 0 - 20 °C 2.2: 272 mg / tetrahydrofuran; toluene / 1 h / 0 °C View Scheme
参考文献
Evans, D. A.; Bartroli, J.
Tetrahedron Letters, 1982 , vol. 23, # 8 p. 807 - 810
反应条件
1.1: 67 percent / Bu2BOTf; diisopropylethylamine / diethyl ether / 2 h / -78 °C 2.1: trimethylaluminum / tetrahydrofuran; toluene / 0 - 20 °C 2.2: 450 mg / tetrahydrofuran; toluene / 1.5 h / 50 °C View Scheme
参考文献
Toyota, Masahiro; Hirota, Masako; Nishikawa, Youichi; Fukumoto, Keiichiro; Ihara, Masataka
Journal of Organic Chemistry, 1998 , vol. 63, # 17 p. 5895 - 5902
