2'-脱氧-5-(苯基乙炔基)-尿苷合成路线 （共 11 条）
反应条件
copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=50°C; 2 h;
参考文献
Crisp; Flynn
Journal of Organic Chemistry, 1993 , vol. 58, # 24 p. 6614 - 6619
反应条件
copper(l) iodide; palladium diacetate; triethylamine; TXPTS in water; acetonitrile
T=65°C; Sonogashira coupling; 0.5 h; Inert atmosphere;
参考文献
Hyung Cho, Joon; Prickett, Caitlin D.; Shaughnessy, Kevin H.
European Journal of Organic Chemistry, 2010 , # 19 p. 3678 - 3683
反应条件
sodium hydroxide in pyridine; ethanol
T=4°C;
参考文献
Hudson, Robert H. E.; Ghorbani-Choghamarani, Arash
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 12 p. 1845 - 1848
反应条件
2: 35 percent / H2O, TEA / Ambient temperature
View Scheme
参考文献
Vincent, Patrice; Beaucourt, Jean-Pierre; Pichat, Louis
Tetrahedron Letters, 1981 , vol. 22, p. 945 - 947
反应条件
sodium methylate in methanol
参考文献
Robins, Morris J.; Barr, Philip J.
Tetrahedron Letters, 1981 , vol. 22, p. 421 - 424
反应条件
1: 91 percent / Et3N / (Ph3P)2PdCl2, CuI / 4 h / 50 °C
2: NaOMe / methanol / 6 h / 25 °C
View Scheme
参考文献
Robins, Morris J.; Barr, Philip J.
Journal of Organic Chemistry, 1983 , vol. 48, # 11 p. 1854 - 1862
反应条件
1: 98 percent / K2CO3 / H2O; dioxane
2: 88 percent / Et3N, copper(I) iodide / Pd(PPh3)4 / dimethylformamide / 2 h / 50 °C
View Scheme
参考文献
Crisp; Flynn
Journal of Organic Chemistry, 1993 , vol. 58, # 24 p. 6614 - 6619
反应条件
1: 89 percent / pyridine / 24 h / 20 °C
2: 90 percent / Et3N / Pd(PPh3)4; CuI / dimethylformamide / 24 h / 20 °C
3: 86 percent / aq. NaOH / pyridine; ethanol / 4 °C
View Scheme
参考文献
Hudson, Robert H. E.; Ghorbani-Choghamarani, Arash
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 12 p. 1845 - 1848
反应条件
1: 90 percent / Et3N / Pd(PPh3)4; CuI / dimethylformamide / 24 h / 20 °C
2: 86 percent / aq. NaOH / pyridine; ethanol / 4 °C
View Scheme
参考文献
Hudson, Robert H. E.; Ghorbani-Choghamarani, Arash
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 12 p. 1845 - 1848
反应条件
TEA; water
Ambient temperature;
参考文献
Vincent, Patrice; Beaucourt, Jean-Pierre; Pichat, Louis
Tetrahedron Letters, 1981 , vol. 22, p. 945 - 947
