trifluoroacetic acid chloride in chloroform T=150°C; 1 h;

phosphorus trichoride 1 h; Heating;

1: 80 percent / copper(II) sulphate / pyridine; H2O / 4 h / Heating 2: 94 percent / CH2Cl2 / 72 h 3: 13 percent / MgCl2 / acetonitrile / 72 h View Scheme

1: 85 percent / acetic acid; H2O / 2.5 h 2: 99 percent / hydroxylamine hydrochloride, sodium hydroxide / ethanol; H2O / 0.5 h 3: 80 percent / copper(II) sulphate / pyridine; H2O / 4 h / Heating 4: 94 percent / CH2Cl2 / 72 h 5: 13 percent / MgCl2 / acetonitrile / 72 h View Scheme

T=20°C; 24 h;

in acetonitrile 72 h;