1: With tris(dibenzylideneacetone)dipalladium (0); 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran
16 h; Heating;
2: With potassium hydroxide in tetrahydrofuran; methanol; diethyl ether
4 h; Heating; Further stages.;
参考文献
Solinas, Maurizio; Meadows, Rebecca E.; Wilson, Claire; Blake, Alexander J.; Woodward, Simon
European Journal of Organic Chemistry, 2007 , # 10 p. 1613 - 1623
1.1: 12.4 g / CH2Cl2 / 12 h / 0 °C
2.1: X-Phos; Pd2(dba)3; (AlMe3)2(DABCO) / tetrahydrofuran / 16 h / Heating
2.2: aq. KOH / tetrahydrofuran; methanol; diethyl ether / 4 h / Heating
View Scheme
参考文献
Solinas, Maurizio; Meadows, Rebecca E.; Wilson, Claire; Blake, Alexander J.; Woodward, Simon
European Journal of Organic Chemistry, 2007 , # 10 p. 1613 - 1623
1.1: 90 percent / DMAP; NEt3 / CH2Cl2 / 8 h / 20 °C
2.1: 12.4 g / CH2Cl2 / 12 h / 0 °C
3.1: X-Phos; Pd2(dba)3; (AlMe3)2(DABCO) / tetrahydrofuran / 16 h / Heating
3.2: aq. KOH / tetrahydrofuran; methanol; diethyl ether / 4 h / Heating
View Scheme
参考文献
Solinas, Maurizio; Meadows, Rebecca E.; Wilson, Claire; Blake, Alexander J.; Woodward, Simon
European Journal of Organic Chemistry, 2007 , # 10 p. 1613 - 1623
