4-甲基-3,4-二氢-2H-苯并[b][1,4]噁嗪合成路线 （共 24 条）
反应条件
1: With ozone in methanol
T=-78°C;
2: With hydrogen; nitrobenzene; palladium on activated charcoal in methanol
T=25°C; P=3040 Torr; 6 h;
参考文献
Bunce, Richard A.; Herron, Derrick M.; Hale, Lu Y.
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1031 - 1039
参考文献
Kotha, Sambasivarao; Kuki, Atsuo
Journal of the Chemical Society, Chemical Communications, 1992 , # 5 p. 404 - 406
反应条件
sodium tetrahydroborate in tetrahydrofuran
T=0 - 5°C; 3 h;
参考文献
Mizar, Pushpak; Myrboh, Bekington
Tetrahedron Letters, 2006 , vol. 47, # 44 p. 7823 - 7826
反应条件
1: 94 percent / trifluoroacetic acid; sodium borohydride / CH2Cl2 / 0.5 h / 20 °C
2: 81 percent / TBAF / tetrahydrofuran / 1 h
3: 72 percent / Pd(OAc)2; Cs2CO3; 9-(2-di-tert-butylphosphanylphenyl)phenanthrene / toluene / 48 h / 70 °C
View Scheme
参考文献
Toracca, Karen E.; Kuwabe, Shin-Itsu; Buchwald, Stephen L.
Journal of the American Chemical Society, 2000 , vol. 122, # 51 p. 12907 - 12908
反应条件
1: 81 percent / TBAF / tetrahydrofuran / 1 h
2: 72 percent / Pd(OAc)2; Cs2CO3; 9-(2-di-tert-butylphosphanylphenyl)phenanthrene / toluene / 48 h / 70 °C
View Scheme
参考文献
Toracca, Karen E.; Kuwabe, Shin-Itsu; Buchwald, Stephen L.
Journal of the American Chemical Society, 2000 , vol. 122, # 51 p. 12907 - 12908
反应条件
1: KOH; acetone
2: LiAlH4
View Scheme
参考文献
Loudon; Ogg
Journal of the Chemical Society, 1955 , p. 739,743
反应条件
1: 100 percent / NaBH4, AcOH / tetrahydrofuran / 18 h
2: K2CO3 / acetone; H2O / 72 h / Heating
View Scheme
参考文献
Kotha, Sambasivarao; Bindra, Vandana; Kuki, Atsuo
Heterocycles, 1994 , vol. 38, # 1 p. 5 - 8
反应条件
1: 73 percent / potassium carbonate / dimethylformamide / 15 h / 125 °C
2: 80 percent / NaBH4 / tetrahydrofuran / 3 h / 0 - 5 °C
View Scheme
参考文献
Mizar, Pushpak; Myrboh, Bekington
Tetrahedron Letters, 2006 , vol. 47, # 44 p. 7823 - 7826
反应条件
hydrogenchloride
T=160°C; Kochen des Reaktionsprodukts mit Natronlauge;
参考文献
Knorr
Chemische Berichte, 1889 , vol. 22, p. 2084
Chemische Berichte, 1897 , vol. 30, p. 918
反应条件
1: 180 °C / Reaktion ueber mehrere Stufen
2: LiAlH4
View Scheme
参考文献
Loudon; Ogg
Journal of the Chemical Society, 1955 , p. 739,743
