(4R,5S)-(+)-4-甲基-5-苯基-2-恶唑啉酮合成路线 （共 61 条）
反应条件
PhCH2OLi in tetrahydrofuran; hexane T=0°C; 1.5 h;
参考文献
Journal of Organic Chemistry, , vol. 50, # 11 p. 1830 - 1835
反应条件
lithium aluminium tetrahydride in diethyl ether T=0°C; 0.0833333 h;
参考文献
Evans, D. A.; Bartroli, J.
Tetrahedron Letters, 1982 , vol. 23, # 8 p. 807 - 810
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-78 - 0°C; 1.5 h;
参考文献
Journal of Organic Chemistry, , vol. 52, # 17 p. 3759 - 3766
反应条件
trimethylaluminum in dichloromethane T=0 - 4°C; 3 h;
参考文献
Samy, Raghu; Kim, Hong Yong; Brady, Matthew; Toogood, Peter L.
Journal of Organic Chemistry, 1999 , vol. 64, # 8 p. 2711 - 2728
反应条件
1: in acetonitrile T=20°C; Acylation; 2 h; 2: With p-toluenesulfonyl chloride in acetonitrile T=25°C; Cyclization; 10 h;
参考文献
Feroci, Marta; Inesi, Achille; Mucciante, Vittoria; Rossi, Leucio
Tetrahedron Letters, 1999 , vol. 40, # 33 p. 6059 - 6060
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=20°C; 2 h;
参考文献
Tetrahedron Letters, , vol. 48, # 39 p. 6845 - 6848
反应条件
potassium carbonate T=110°C; 6 h;
参考文献
Evans; Mathre; Scott
Journal of Organic Chemistry, 1985 , vol. 50, # 11 p. 1830 - 1835
反应条件
osmium(VIII) oxide; trimethylamine-N-oxide in water; acetone; tert-butyl alcohol T=20°C; Oxidation; cyclization; 2 h;
参考文献
Tetrahedron, , vol. 56, # 30 p. 5303 - 5310
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=20°C; cleavage; 16 h;
参考文献
Braddock, D. Christopher; Brown, John M.
Tetrahedron Asymmetry, 2000 , vol. 11, # 17 p. 3591 - 3607
反应条件
1: O,N-dimethyl-hydroxylamine hydrochloride With trimethylaluminum in tetrahydrofuran; toluene T=0 - 20°C; 2: (4R,5S)-3-((E)-(2R,3R)-3-Hydroxy-2,4-dimethyl-hept-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one in tetrahydrofuran; toluene T=0°C; 1 h;
参考文献
Tetrahedron, , vol. 60, # 38 p. 8509 - 8527
