(4R,5S)-(+)-4-甲基-5-苯基-2-恶唑啉酮合成路线 （共 61 条）
反应条件
1: (+)-Norephedrine in acetonitrile T=20°C; Electrolysis; 2: carbon dioxide 1 h; 3: p-toluenesulfonyl chloride T=20°C;
参考文献
Tetrahedron Letters, , vol. 43, # 33 p. 5863 - 5865
反应条件
1: monoiodonaphthalene With n-butyllithium; isopropylmagnesium chloride in tetrahydrofuran; hexane T=-20 - -5°C; 2: C20H24N2O4S2 in tetrahydrofuran; hexane T=-30°C; 0.5 h;
参考文献
Silveira, Gustavo P.; Marino, Joseph P.
Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3379 - 3383
反应条件
zinc(II) chloride; lithium diisopropyl amide in tetrahydrofuran T=-60 - 20°C; 0.5 h;
参考文献
Magano, Javier; Nanninga, Thomas N.; Winkle, Derick D.
Tetrahedron Letters, 2008 , vol. 49, # 18 p. 2956 - 2959
反应条件
sodium hydroxide in diethyl ether; toluene 2.5 h; Ambient temperature;
参考文献
Ku, Thomas W.; Kondrad, Karen H.; Gleason, John G.
Journal of Organic Chemistry, 1989 , vol. 54, p. 3487 - 3491
反应条件
pyridine; p-toluenesulfonyl chloride Heating; Yield given. Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 34, # 28 p. 4509 - 4512
反应条件
1: 95 percent / ethyl acetate / 12 h / Heating 2: p-toluenesulfonyl chloride / pyridine / RT, 3 d; reflux, 6 h View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 132, # 8 p. 808 - 814
反应条件
1: 1.) LDA / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) from -25 deg C to 0 deg C 4 h 2: 75 percent / LiOBn / tetrahydrofuran; hexane / 1.5 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 11 p. 1830 - 1835
反应条件
1: 1.) LDA / 1.) THF, hexane -78 deg C, 0.5 h, 2.) a) -78 deg C, 1 h, b) from -78 deg C to 0 deg C, 2.5 h 2: 70 percent / LiAlH4 / tetrahydrofuran / 1.5 h / -78 - 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 52, # 17 p. 3759 - 3766
反应条件
molecule imprinted polymer in acetonitrile T=25°C; pH=7; Resolution of racemateaq. phosphate buffer;
参考文献
Bulletin of the Korean Chemical Society, , vol. 33, # 5 p. 1664 - 1668
反应条件
trimethylaluminum 1) CH2Cl2, toluene, RT, 15 min; 2) CH2Cl2, -10 - 0 deg C, 1 h, 0 deg C, 2 h, RT, 0.5 h; Yield given. Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 110, # 8 p. 2506 - 2526
