(4R,5S)-(+)-4-甲基-5-苯基-2-恶唑啉酮合成路线 （共 61 条）
反应条件
potassium hydroxide 1.) 50 deg C, 3 h, 2.) reflux, 3 h; Yield given;
参考文献
Journal of Organic Chemistry, , vol. 53, # 23 p. 5415 - 5421
反应条件
benzyl N-(1H-benzotriazol-1-ylmethyl)carbamate; lithium diisopropyl amide in tetrahydrofuran
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 3 p. 521 - 528
反应条件
1: 1 M aq. NaOH / 0.67 h / Ambient temperature 2: 1 M methanol. KOH / 1.) 50 deg C, 3 h, 2.) reflux, 3 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 23 p. 5415 - 5421
反应条件
n-butyllithium in tetrahydrofuran; hexane T=0°C; 1 h; epimerisation; also (4R,5S)-(-)-4-methyl-5-phenyl-2-oxazolidine;
参考文献
Tetrahedron: Asymmetry, , vol. 4, # 12 p. 2513 - 2516
反应条件
T=180 - 200°C; 4 h; Further byproducts given;
参考文献
Cruz, Alejandro; Contreras, Rosalinda; Padilla-Martinez, Itzia I.; Juarez-Juarez, Minerva
Tetrahedron Asymmetry, 2006 , vol. 17, # 10 p. 1499 - 1505
参考文献
Journal of Organic Chemistry, , vol. 62, # 23 p. 7914 - 7915
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Tanasova, Marina; Borhan, Babak
European Journal of Organic Chemistry, 2012 , # 17 p. 3261 - 3269
反应条件
electrogenerated base from 2-pyrrolidone; N(Et)4ClO4 in acetonitrile T=20°C;
参考文献
Feroci; Inesi; Palombi; Rossi; Sotgiu
Journal of Organic Chemistry, 2001 , vol. 66, # 18 p. 6185 - 6188
反应条件
n-butyllithium
1.) THF, -78 deg C, 15 min; 2.) THF, -78 deg C, 30 min then 0 deg C, 15 min;
参考文献
Evans,D.A.; Chapman,K.T.; Bisaha,J.
Journal of the American Chemical Society, 1988 , vol. 110, p. 1238
反应条件
4-(N,N-dimethlyamino)pyridine; diisopropyl-carbodiimide in dichloromethane
T=20°C; Acylation; 29 h;
参考文献
Graham, James M.; Shireman, Brock T.; Maddux, Todd M.; Brandstedt, Christina M.; Zeller, Wayne E.
Synthetic Communications, 2000 , vol. 30, # 7 p. 1221 - 1226
