1,4-苯并二氧杂环己烷-2-甲酰氯合成路线 （共 5 条）
反应条件
1: 90 percent / benzene / 3 h / Heating View Scheme
参考文献
Coudert, Gerard; Borredon-Watrin, Corinne; Guillaumet, Gerald
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 609 - 612
反应条件
thionyl chloride in benzene
6 h; Heating;
参考文献
Lalloz, Lucien; Loppinet, Vincent; Coudert, Gerard; Guillaumet, Gerald; Loubinoux, Bernard; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 994 - 998
反应条件
1: 93 percent / 8percent NaOH / 1 h / 95 °C
2: 100 percent / thionyl chloride / benzene / 6 h / Heating
View Scheme
参考文献
Lalloz, Lucien; Loppinet, Vincent; Coudert, Gerard; Guillaumet, Gerald; Loubinoux, Bernard; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 994 - 998
反应条件
1: sodium iodide / acetone / 1.5 h / Ambient temperature
2: 93 percent / 8percent NaOH / 1 h / 95 °C
3: 100 percent / thionyl chloride / benzene / 6 h / Heating
View Scheme
参考文献
Lalloz, Lucien; Loppinet, Vincent; Coudert, Gerard; Guillaumet, Gerald; Loubinoux, Bernard; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 994 - 998
反应条件
1: N-bromosuccinimide (NBS), benzoyl peroxide / CCl4 / 6 h / Heating
2: sodium iodide / acetone / 1.5 h / Ambient temperature
3: 93 percent / 8percent NaOH / 1 h / 95 °C
4: 100 percent / thionyl chloride / benzene / 6 h / Heating
View Scheme
参考文献
Lalloz, Lucien; Loppinet, Vincent; Coudert, Gerard; Guillaumet, Gerald; Loubinoux, Bernard; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 994 - 998
