palladium diacetate in diethyl ether T=5°C; 0.166667 h;

1: potassium hydroxide / aq. ethanol / 1 h / Heating 2: oxalyl chloride / CH2Cl2 / 2.5 h / Heating View Scheme

bromine in dichloromethane T=-70°C; 1.5 h;

暂无反应条件数据

N,N,N',N',N'',N''-hexamethylphosphoric triamide; iron(II) chloride T=125 - 130°C; 18 h; other reagents, temperatures, times; yield optimization;

1: potassium hydroxide / aq. ethanol / 1 h / Heating 2: 96.1 percent / aq. NaHCO3, I2, KI / 1 h / Ambient temperature 3: 79.1 percent / potassium carbonate / 1.5 h / Ambient temperature 4: 20.4 percent / LiN(SiMe3)2 / tetrahydrofuran; hexane / 4 h / -30 °C 5: 1.) sodium hydride / 1.) THF, RT, 20 min, 2.) THF, reflux, 5h 6: 100 percent / 30percent aq. hydrogen peroxide / methanol / 120 h / Ambient temperature 7: 44.5 percent / trifluoroacetic anhydride, 2,6-lutidine / acetonitrile / 4 h / -25 °C 8: 91 percent / iodine / 15 h / Ambient temperature 9: 32.3 percent / 10percent aq. hydrochloric acid / tetrahydrofuran / 55 h / Ambient temperature 10: 1.) 2,6-lutidine, trifluoroacetic anhydride; 2.) potassium carbonate / 1.) acetonitrile, -30 deg C, 2h; 2.) acetonitrile, RT, 1 h 11: 76.7 percent / iodine / 24 h / Ambient temperature View Scheme

1: 86 percent / BPO / 20 h / 80 °C 2: 87 percent / pyrrolidine / toluene / 4 h / 100 - 110 °C View Scheme

1: 60 percent / 10 h / Ambient temperature; Irradiation 2: 51 percent / EtONa / ethanol / 2 h / ice-cooling View Scheme

hydrogenchloride; sodium ethanolate in toluene

2,2'-azo-bisisobutyronitrile in trichloromonobromomethane